Chimbetete, Cleophas (2011) Factors Associated with 1st Line ART Failure among Patients at Newlands Clinic, Harare 2011. Masters thesis, University of Zimbabwe.
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Abstract
Introduction: First line ART treatment failure occurs when drugs being administered for the treatment of HIV are no longer able to kill the virus i.e. virus would have developed resistance to the drugs. This study sought to determine factors associated with 1st line treatment failure among patients taking ART at Newlands clinic, Harare. Materials and methods: An unmatched 1:1 case control study was conducted at Newlands Clinic. Patients who had been on ART for at least 6 months were eligible for study participation. Questionnaires were used to collect data and a review of patient records was done. Results: A total of 464 participants were enrolled into the study. Median age of cases was 33.5 (Q1= 17, Q3 =45) and 37 for controls (Q1=27.5, Q3=37). Females represented 58.1% of study population and 41.9% were males. Median duration on ART for cases was 3.1 years (Q1=2.01, Q3=4.7 years) and 2.9 years for controls (Q1=1.96, Q3= 4.64). Independent risk factors associated with treatment failure were: Not being married (AOR= 1.8: 95% CI 1.01- 3.21), ART commencement by private doctor (AOR =4.86: 95% CI 2.11- 11.2), WHO stage 3 / 4 at ART commencement (AOR=2.08: 95% CI 1.21- 3.57), poor adherence to treatment (AOR=1.73: 95% CI 1.01-3.21) and CD4 <50 at ART commencement (AOR=1.5: 95% CI 1.65- 8.20) Discussion: Late commencement of ART increases the risk of treatment failure. ART commencement by private doctors is a risk factor for failure due to poor patient preparation for ART at private surgeries. Unmarried people are less likely to have good adherence support and hence increased risk of failure.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | First line ART, Treatment Failure, Newlands Clinic |
| Subjects: | Q Science > QR Microbiology R Medicine > R Medicine (General) |
| Divisions: | Africana |
| Depositing User: | Geoffrey Obatsa |
| Date Deposited: | 24 Apr 2018 07:50 |
| Last Modified: | 24 Apr 2018 07:50 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/3754 |
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