Abera, Demeke (2016) Simultaneous Determination of Dopamine and Pyridine-2- Aldoxime Methochloride at Poly (3, 4-Ethylenedioxythiophene) Modified Glassy Carbon Electrode. Masters thesis, Addis Ababa University.
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PDF (Simultaneous Determination of Dopamine and Pyridine-2- Aldoxime Methochloride at Poly (3, 4-Ethylenedioxythiophene) Modified Glassy Carbon Electrode)
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Abstract
A sensitive and selective method was developed for the simultaneous determination of Dopamine (DA) and Pyridne-2-alidoxime methochiloride (PAM-2) with poly (3, 4- ethylenedioxythiophene) (PEDOT) modified glassy carbon electrode (GCE). Cyclic voltammetry and Square wave adsorptive stripping voltammetry (SWAdSV) were used to investigate the electrochemical reaction of DA and PAM-2 at the PEDOT modified electrode. DA and PAM-2 were showed a diffusion control and adsorption control reaction mechanisms, in phosphate buffer solution of pH 7.0 respectively. The significant anodic peak potential difference (525 mV) between DA and PAM-2 enabled the simultaneous determination of both species based on Square wave adsorptive stripping voltammetry. The voltammetric responses gave linear ranges of 5×10−7–1.0×10−4 mol L−1 and 5.0×10−6 –15.0×10-5 molL−1, with detection limits of 3.1×10−8 molL−1 and 1.91×10−7molL−1 for DA and PAM-2, and The method was successfully applied for the determination of DA and PAM-2 in biological samples, with in a very good recovery result 101.57 % and 95.17 % respectively.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Dopamine (DA), Pyridine-2-aldoxime methochloride (PAM-2), Glassy carbon electrode (GCE), Poly (3, 4-ethylenedioxythiophene) (PEDOT), Cyclic voltammetry (CV) and Square wave adsorptive stripping voltammetry (SWAdSV) |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry T Technology > T Technology (General) |
| Divisions: | Africana |
| Depositing User: | Selom Ghislain |
| Date Deposited: | 18 Jun 2018 09:12 |
| Last Modified: | 18 Jun 2018 09:12 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/4281 |
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