Mengiste, Berhan (2008) Antiplasmodial Activity of Extracts from Dodonaea Angustifolia L.F. and Bersama Abyssinica Fresen against Plasmodium Berghei in Mice Model. Masters thesis, Addis Ababa University.
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Abstract
The seed of Dodonaea angustifolia and root bark of Bersama abyssinica are traditionally used for the treatment/prophylaxis of malaria in some malarous areas in Ethiopia. The aim of this study is to evaluate antiplasmodial activity and study acute toxicity of Dodonaea angustifolia and Bersama abyssinica in P. berghei infected mice. In the present study, aqueous and methanol extracts of D. angustifolia and B. abyssinica were investigated for their antimalarial activity using Peters’ 4-day suppressive test against P. berghei infection in mice. The crude extracts and the fractions of the most active extract were orally administered to screen their antimalarial properties. The extracts significantly inhibited parasitemia and prevented PCV fall (p <0.05) dose-dependently. They increased the survival time of the infected mice. However, the extracts from both plants did not prevent body weight loss. The aqueous extract of D. angustifolia was found to be most active producing 35.79% chemosuppression. From this extract, three fractions were produced and tested in vivo against P. berghei in mice. The butanol fraction was found to be the most active producing percentage inhibition of 48.6% at 100 mg/kg. This fraction was also found to prevent PCV, body weight and temperature reduction significantly. The test substances showed only low toxicity (LD50=5044 mg/kg for B. abyssinica and no mortality for D. angustifolia up to 4500 mg/kg). The results obtained from the present work support the traditional use of these plants for treatment of malaria.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Malaria, Drug resistance, Dodonaea angustifolia, Bersama abyssinica, Plasmodium berghei and LD 50 |
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 21 Jun 2018 07:05 |
| Last Modified: | 21 Jun 2018 07:05 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/5286 |
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