Eshetu, Bezalem (2014) Survival Time and Immunological Recovery of AIDS Patients under Antiretroviral Treatment: A Case Study at Felege Hiwot Referal Hospital, Bahir-Dar, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Antiretroviral Treatment (ART), although not a cure, can help people from becoming ill for many years and this has improved the survival and recovery time of HIV patients. In 2011 a number of 249,174 adults were on ART in Ethiopia. Although ART treatment has decreased HIV associated mortality and morbidity, a number of patients still die after the start of ART. The purpose of this study was to identify factors affecting the survival time and time to immunological recovery of HIV/AIDS patients under ART treatment. A sample of 387 patients was taken from patients’ records at Bahir-Dar Felege-Hiwot Referral Hospital from June 2006 to August 2013. Kaplan-Meier estimation method and Cox proportional hazard model were applied to describe and analyze the data. Females, baseline CD4 count >200cell/µl, TB-negative, total lymphocyte count ≥1200 cell/mm3 and baseline weight ≥45kg, no regimen change, good adherence to treatment, WHO stage I, working functional status and negative-anemia were identified with longer survival time and shorter recovery time at 5% of significance level. Patients having no risk behaviors lived longer. Based on the Cox regression model results the adjusted HRs were as follows: high CD4 count (aHR=0.99), negative-anemia patients (aHR=0.27), good adherence to treatment (aHR=0.10), fair adherence to treatment (aHR=0.47), male gender (aHR=1.81), TB-positive (aHR=3.58), bedridden functional status (aHR=5.07), ambulatory functional status (aHR=1.30). The adjusted HRs for recovery time were as follows: patients with high CD4 count (aHR=1.02), high weight (≥45kg.) (aHR=1.03), WHO stage I (aHR=1.88), WHO stage II (aHR=1.67) and negative-anemia (aHR=1.34) had shorter time to immunological recovery at 5% level of significance. Male gender (aHR =0.73), old age (aHR=0.98), total lymphocyte count <1200 (aHR=0.77) and regimen change (aHR=0.688) were significantly associated with extended time to immunological recovery at 5% level.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | H Social Sciences > H Social Sciences (General) H Social Sciences > HA Statistics R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Selom Ghislain |
| Date Deposited: | 19 Sep 2018 14:31 |
| Last Modified: | 19 Sep 2018 14:31 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/5378 |
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