Sidamo, Temesgen (2010) Wound Healing Activity of Kalanchoae Petitiana Leaf Extracts in Mice. Masters thesis, Addis Ababa University.
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Abstract
Kalanchoae petitiana (Crassulaceae) is known for its use in traditional medicine in different areas of Ethiopia. The plant is traditionally claimed to be used in the treatment of tapeworms, trachoma, syphilis, different swellings, epilepsy, rabies, constipation and hemorrhoid etc. This work deals with the wound healing potential of 80% methanolic and chloroform extracts of the plant leaves. To this end, the study was conducted by using incision, excision, and dead-space wound models in mice. For excision and incision wounds ointment and gel preparations of the methanolic and chloroform extracts, respectively, were used whereas oral suspension of the methanolic extract was employed in dead space wound. The parameters studied for the evaluation of the wound healing activity of the plant include rate of wound contraction and period of complete epithelialization in excision wound, skin breaking strength of incision wound, and granulation tissue wet and dry weights and the hydroxyproline contents in dead space wound. The 80% methanolic extract of the plant was found to possess significant wound healing(P<0.01) activity, as it was evidenced by decrease in the period of epithelialization, increase in the rate of wound contraction, higher skin breaking strength, increase in granulation tissue wet and dry weights and increased hydroxyproline content in the three experimental models as compared to controls. However, the wound healing effect of the chloroform extract was found to be weaker in that it showed significant healing (P<0.05) only in incision wound in the larger dose (10% gel). The results of the 5% and 10% chloroform extract gel in excision wounds were not significantly different from the control values. Also tests for anti-inflammatory and antioxidant activities were carried out with the methanolic extract of the plant and the results were found to be positive. The results of this study support the traditional claim for the wound healing activity of the extracts of Kalanchoae petitiana. Other activities such as anti-inflammatory and antioxidant activities seem to corroborate the wound healing activity of the plant.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Wound healing, Kalanchoae petitiana, Anti-inflammatory activity, Antioxidant activity |
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 21 Jun 2018 14:04 |
| Last Modified: | 21 Jun 2018 14:04 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/5391 |
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