Jemal, Abdurazak (2015) Evaluation of the Diuretic Activity of Aqueous and 80% Methanol Extracts of Foeniculum Vulgare Mill (Apiaceae) Leaf in Rats. Masters thesis, Addis Ababa University.
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Abstract
Evaluation of the diuretic activity of aqueous and 80% methanol extracts of Foeniculum vulgare Mill. (Apiaceae) leaf in rats Abdurazak Jemal Addis Ababa University, 2015 The leavf of Foeniculum vulgare is used in Ethiopian traditional medicines as a diuretic agent for the treatment of urine retention and hypertension. As this claim has not been investigated scientifically, the aim of this study was to evaluate the diuretic effect of the aqueous and 80% methanol leaf extracts of Foeniculum vulgare in rats. Spargue Daweley rats were divided into eight groups each comprising six rats. Control group received distilled water 10 mL/kg, the reference group received hydrochlorthiazide 10 mg/kg and the test groups were administered different doses of aqueous or 80% methanol extract (100, 200 and 400 mg/kg) orally. Urine output was collected up to 24 h and analyzed for electrolyte contents. Rats treated with 200 and 400 mg/kg doses of aqueous and 80% methanol extract of Foeniculum vulgare displayed an increased urine volume (p<0.001). However, 100 mg/kg dose of both extracts failed to produce significant increase in 24 h urine volume compared to control groups. Both extracts increased natriuresis, kaliuresis and chloriuresis (p<0.001) at the middle and higher doses. The result indicated that the plant is endowed with significant activity, aqueous being better than 80% methanol extract, providing proof for the traditional claim. The major constituents like flavonoids, tannins, terpenoids and alkaloids found in the plant might have contributed to the observed diuretic activity.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Foeniculum vulgare, Diuretic Activity, Natriuresis, Kaliuresis |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 01 Oct 2018 14:17 |
| Last Modified: | 01 Oct 2018 14:17 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/5763 |
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