Treatment Outcomes of Portal Hypertension in Children; Tikur Anbessa Specialized Hospital

Gebreegziabher, Abraha (2014) Treatment Outcomes of Portal Hypertension in Children; Tikur Anbessa Specialized Hospital. Other thesis, Addis Ababa University.

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Background: The mortality of portal hypertension in conservatively treated cases is high, e.g. reported 40% death in a few years of the first hematemesis; 30% of children may die in 30 days up to 6 weeks of first episode of hematemesis. Recurrent bleeding is still causing 20 to 30% deaths in the presence of interventional procedures, too. This study focuses on actuarial survival at one, two, and three years of diagnosis of portal hypertension and does attempt to find out impacting factors. Aim: To determine the treatment outcome of portal hypertension in children in the study period Methods: The study was conducted from February 01, 2012 to August 30, 2014, through retrospective chart review, in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. P- Value of 0.05 was used as a level of significance. Results: A total of 42 patients aging 2 months up to 14 years at the time of first hospital visit were found and of whom 28 (66.7%) were males and 14 (33.3%) were females. After their diagnosis, 26 (61.9%) were living more than 1 year, 12 (28.7%) between 3-5 years, 5(11.9%) more than 5 years, and 1 (2.4%) went critically sick in the first visit against medical advice. Only 4 (9.5 %) are followed for less than and/or since 4 weeks; still one of these was not missing follow up. Conclusion: Four week survival after diagnosis is higher compared to previous studies, which were showing 20-30% mortality and the prevention of recurrences of hematemesis by Propranolol demonstrated (p= 0.021), while there was no significant association with the time length of survival after diagnosis (p=0.084) for the patients on Propranolol. Survival was negatively affected by jaundice, Ascites, and hypersplenism at presentation.

Item Type: Thesis (Other)
Subjects: R Medicine > RJ Pediatrics
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: Africana
Depositing User: Vincent Mpoza
Date Deposited: 02 Oct 2018 12:46
Last Modified: 02 Oct 2018 12:46

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