Kefeany, Genet (2017) Status of Vitamin B12 Level among Type 2 Diabetes Mellitus Patients on Metformin Treatment Attending Diabetic Clinic of the Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Metformin is a standard therapy, most commonly prescribed oral anti-hyperglycemic agent for individuals with type-2 diabetes (T2DM). Many studies also documented the association between long-term metformin use and low vitamin B12 levels among individuals with T2DM; however, metformin-induced vitamin B12 deficiency(VBD) prevalence estimates showed large variation among studies. To the best of our knowledge, studies on the association between long term metformin use and low vitamin B12 levels among individuals with T2DM are not found in Ethiopia. Objective: To determine the status of vitamin B12 level and risk factors associated with its deficiency in patients with type 2 diabetes mellitus on metformin treatment attending diabetes clinic of the Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia. Methods: Institutional based cross-sectional study was conducted from March 12/ 2017 to May 15/2017 at diabetes clinic of TASH. Convenient sampling method was used to include a total of 121 T2DM patients with and without metformin treatment. Blood samples were collected and Vitamin B12 levels were determined by Cobas e411 analyzer by electro chemiluminescence immunoassay. Neuropathy Total Symptom Score-6 questionnaire (NTSS-6 scores) was used to compare severity of Peripheral neuropathy (PN) in both groups. VBD was defined as serum concentration of <200 pg/dl. NTSS-6 scores >6 is considered to have PN. Finally data was entered and analyzed through SPSS version 20 computer software packages. Results: From the total of 121 study participants serum B12 levels were low(<200pg/ml) in 15(21.1%) T2DM patients with metformin (n=71) as compared to 2 patients (4.0%) without metformin treatment(n=50). Mean B12 level with metformin was found to be 331.58 pg/ml(± 134.48) as compare to those without metformin 482.23pg/ml(± 235.24), the difference was stastically significant with p value <0.001.The factors that interfered with serum B12 levels were duration of diabetes, dose and duration of metformin use. Vitamin B12 levels and NTSS-6 scores were not correlated (Spearman’s rho =0.021, P=0.819). Conclusion: Among patients with T2DM treated with metformin had low serum B12 levels than patients not treated by metformin with significant effect of metformin dose and duration on B12 levels. The deficiency was not associated with peripheral neuropathy.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Type 2 Diabetes Mellitus, Status, Vitamin B12 deficiency, Metformin, neuropathy |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 29 Jun 2018 09:45 |
| Last Modified: | 29 Jun 2018 09:45 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6083 |
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