Seyoum, Getachew (2015) Multidrug Resistant Bacteria in Postoperative Wound Infection at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Post operative wound infection is hospital acquired infection and it is the major cause of morbidity and mortality throughout the world especially in developing countries. Drug resistance is the challenge for controlling such bacteria now days. Assessing the prevalent bacteria and testing their antibiotic susceptibility helps to provide effective therapies, develop rational prescription writing and make policy decisions. Objective: To determine the prevalence of multidrug resistant bacteria in postoperative wound infection. Method: A cross sectional study was conducted from March 30 to August 28/2015 at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A total of 197 study participants who had been diagnosed for post operative wound infection during the study period were included. All collected pus samples were cultured on Blood, MacConkey and Mannitol salt agar. All culture positive samples were characterized by gram stain and standard biochemical tests. Bacterial antimicrobial susceptibility test was performed on Muller-Hinton agar using Kirby-Bauer method. Results: The overall prevalence was 75.6% (n=149/197) and the predominant bacteria isolated were S. aureus33.3% (n=56/168), E. coli 14.3% (n=24/168 and Coagulase negative Staphylococci 11.3% (n=19/168). Double infections 11.4% (n=17/149) were seen in which S. aureus and Pseudomonas species showed common association 23.5% (n=4/17). Multidrug resistances were recorded in 65.5% (n=110/168) of all bacterial isolates. Gram positive and Gram negative isolates showed 55.3% (n=42/76) and 73.9% (n=68/92) multiple drug resistance respectively. Among the antibiotics tested amoxicillin (93.5%), Ceftriaxone (85.3%), Penicillin (84.5%) and Cefotaxime (82.7%) showed high level of resistance. Clindamycin (7.9%) and Amikacin (1.1%) showed high sensitivity for Gram Positive and Gram negative respectively Conclusion: The choice of drugs in the treatment of bacterial isolates from postoperative wound infections is quite narrow today due to the wide scale resistance of pathogens to common drugs. Rational use of antibiotics and a regular monitoring of antimicrobial resistance patterns in postoperative wound infections are essential and mandatory to prevent further emergence and spread of anti-microbial resistance among bacterial pathogens.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | postoperative wound infections, Multidrug resistance bacteria, Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia |
| Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 28 Jun 2018 10:07 |
| Last Modified: | 28 Jun 2018 10:07 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6143 |
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