Tsegaye, Getahun (2016) Effects of Natural Honey on Streptozotocin Induced Diabetic Mice. Masters thesis, Addis Ababa University.
![[img]](http://thesisbank.jhia.ac.ke/style/images/fileicons/application_pdf.png) |
PDF (Effects of Natural Honey on Streptozotocin Induced Diabetic Mice)
Getahun Tsegaye.pdf - Accepted Version Restricted to Repository staff only Download (1MB) | Request a copy |
Abstract
Background: Despite the discovery of many synthetic medicines for diabetes mellitus, it has never been reported that someone has been improved from complication resulted from diabetes mellitus. The rapid increase in diabetic patients, drug related toxicity and cost of treatments have initiated a search for an impressive array of anti-diabetes. As a result, there is still a great need for novel anti-diabetes compounds from natural products such as natural honey for their chemical diversity, structural complexity and broad spectrum. The potential of natural honey as a source of novel drugs remains virtually unexplored and make it candidate for diabetes mellitus. Objective: The aim of this study was to investigate the Effect of Natural Honey on Streptozotocin-Induced type-2 Diabetic Mice. Methodology: Thirty six male mice were randomly divided into six groups. Normal mice received distilled water (0.5ml), normal mice received honey 1 gm/kg, diabetic mice received distilled water (0.5ml), Glibenclamide treated diabetic mice 0.6 mg/body weight , and honey treated diabetic mice 1gm/kg and diabetic mice treated with both Glibenclamide0.6mg/kg and natural honey 1gm/kg respectively. Diabetes was induced by a multiple dose of Streptozotocin (40 mg/kg; i.p.). The animals were treated according to their group by oral gavages once daily for four weeks. At the end of the treatment the animals were sacrificed by anesthetized by diethyl ether and their blood sample was collected. Results: The animals grouped in diabetic control showed hyperglycemia (459±45mg/dL) while groups natural honey treated diabetic mice (220±6.5mg/dL), It reduced their blood glucose level with p-values (p<0.05). While, Glibenclamide treated diabetic mice had 140±19.0mg/dL blood glucose. However, the normal mice treated by natural honey and distilled water did not show any significant changes on their blood glucose and body weight. Those treated with natural honey and Glibenclamide reduced level blood glucose to (120mg/dL±5.0) (p<0.05). Honey alone and in combination with Glibenclamide also significantly reduced triglycerides, total cholesterol, LDL, increased HDL. And also natural honey and glibenclemid treated mice show improvement on their liver function tests such as AST, ALT and ALP. Conclusion: The results of the present study demonstrated that consuming natural honey with gilebinclamide improves hyperglycemia,lipid abnormalities, and also have hepatoprotective effect than consuming gilebinclamide alone.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Diabetes mellitus, streptozotocin, glibenclamide, natural honey |
| Subjects: | Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 29 Jun 2018 07:50 |
| Last Modified: | 29 Jun 2018 07:50 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6154 |
Actions (login required)
 |
View Item |