Seid, Getachew (2017) Helicobacter Pylori Infection among Dyspeptic and Non-Dyspeptic HIV Patients at Yeka Health Center, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Helicobacter pylori is a potent producer of urease. HIV infected patients experience many form of opportunistic infections including gastrointestinal symptoms. The exact role of H. pylori infection among HIV infected patients in causing gastrointestinal symptoms such as dyspepsia remains unclear. There are limited data regarding H. pylori infection in HIVpositive patients in relation to CD4 count in our region and country. Objectives: To assess the prevalence of Helicobacter pylori infection using stool antigen among dyspeptic and non -dyspeptic HIV patients at Yeka health center, Addis Ababa, Ethiopia. Methods: A case control study enrolling 370 study participantswas conducted from JanuaryJune 2017. Socio-demographic and clinical data were collected and3 milliliter blood was drawn aseptically for CD4+T cell count and complete blood count. Stool samples were collected for H. pylori stool antigen test. All necessary data were recorded on questionnaires and data sheet. Data entry and analysis was done using SPSS version 20.Logistic regression analysis was used to see the relation between dependent and independent variables. Results: Of the 370 (185 dyspeptic and 185 non-dyspeptic) study participants, H. pyloriantigen was detected in 117 (31.62%) participants. The prevalence of H. pylori infection was slightly higher in dyspepsia patients 60/185 (32.43%) than non-dyspepsia 57/185 (30.81%) individuals [AOR=1.097, 95% CI: 0.689-1.747, p=0.697]. The infection was significantly associated with gender in non dyspepsiapatients [AOR=2.612, 95% CI: 1.338-5.099, p=0.015] whilein nondyspepsia patients the association was not significantly [AOR=0.805, 95% CI: 0.393-1.648), p=0.639]. In both patient groups, no significant association was observed in the prevalence of H. pylori with age, family size, educational status, marital status, toilet use habit, occupation,alcohol drinking, cigarette smoking and khat chewing (p>0.05). In both case and control group H.pylori infection was higher in patients with CD4T cell count greater than 200cells/μl. Conclusion: The prevalence of H. pylori infection was slightly high among symptomatic than non-symptomatic patients. The infection was not significantly associated with sociodemographic and behavioral factors while it was higher in patients with higher CD4 T cell count.The observed prevalence of H. pylori stool antigen positivity necessitates the need to design and apply intervention measures that could decrease transmission and thus minimize the clinical consequences of infection.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Dyspepsia, Non-dyspepsia, Helicobacter pylori, Prevalence, Stool Antigen Test |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 28 Jun 2018 10:31 |
| Last Modified: | 28 Jun 2018 10:31 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6155 |
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