Tesfamariam, Alias (2016) Comparative Study between DPP-4 Inhibitors Based Therapies and Other Non-Insulin Based Therapies among Type 2 Diabetes Patients in Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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PDF (Comparative Study between DPP-4 Inhibitors Based Therapies and Other Non-Insulin Based Therapies among Type 2 Diabetes Patients in Addis Ababa, Ethiopia)
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Abstract
Background: Type-2 diabetes mellitus is characterized by hyperglycemia as a result of defects in insulin secretion or insulin action. Over the years, attempts to regulate diabetics therapeutically through glycemic control have reduced complications and trauma associated with the disease. Objective: The aim of the present study was to compare the effect of DPP-4 inhibitors based therapies and non-insulin based therapies among type-2 diabetic patients attending diabetic clinics at Tikur Anbessa Specialized Hospital, and Huleshet Higher Private Clinic, Addis Ababa, Ethiopia. Methods: Hospital based cross-sectional study was conducted between the two types of treatment strategies among type-2 diabetic patients. Sixty type-2 diabetic patients were randomly selected from patients attending diabetic clinic at Tikur Anbessa Specialized Hospital, who were receiving non-insulin based therapies and 30 type-2 diabetic patients who were receiving DPP-4 inhibitors based therapies from Huleshet Higher Private clinic were included in this study. Results: The mean total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), serum urea and serum creatinine were significantly lower in type-2 diabetic patients who received DPP-4 inhibitors based therapies than non-insulin based treated type-2 diabetic patients. The mean value of high density lipoprotein (HDL) was also significantly higher as compared to type-2 diabetic patients who were receiving non-insulin based therapies. The mean value of body mass index (BMI) and fasting blood sugar (FBS) were lower in the DPP-4 inhibitors based therapies as compared to non-insulin based treated type-2 diabetic patients but statistically not significant (p>0.05). Among diabetic patients, females had higher level of FBS, TG, LDL, serum urea, BMI and lower level of TC, HDL and serum creatinine as compared to males in both groups. However, the differences were not statistically significant (p>0.05). Conclusion: The DPP-4 inhibitors based therapy helps in normalizing lipid profiles, FBS and also better adjustments in kidney clearance pattern. It also as a result helps in adjusting the weight to height ratios and helps to maintain BMI in the normal range.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Type-2 diabetes, DPP-4, Lipid profile, Renal function test, Incretin-based therapy, Body mass index |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 28 Jun 2018 10:32 |
| Last Modified: | 28 Jun 2018 10:32 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6156 |
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