Mehari, Aman (2013) Establishment of Reference Intervals to Value of Thyroid Function Tests in Cord Blood of Neonates Born in two Hospitals, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Introduction:-Reference intervals are ranges of upper and lower limits outside of which values would be considered abnormal. It depends on the type of instrument and reagents, the principle or method and the type of population being served. Therefore it is obvious that it should be established for every population in different regions even within a country. Objective:-The aim of this study is to establish population specific reference intervals of thyroid stimulating hormone, free thyroxine and free triidothyronine levels of cord blood. Materials and methods፡- A cross sectional study was conducted from July, 2013 to November, 2013 using cord blood sample from 123 new born infants of both sexes born at Tikur Anbessa Teaching Specialized Hospital and Gandhi Memorial Hospital. Thyroid stimulating hormone, free thyroxine and free triidothyronine were measured using Elecsys 2010 immunoassay analyzer at Ethiopian Health and Nutrition Research Institute. The non-parametric method of reference range determination was used. Results:- 123 Cord blood samples collected from umbilical cord of newborns were analyzed for thyroid stimulating hormone, free thyroxine and free triidothyronine values. The birth weights ranged between 2500g to 4700g with mean (SD) value of 3241.46(459.495)gram. Their gestational age ranged between 37 to 44 weeks with an average of 39.74 weeks. The 2.5th and 97.5th percentiles of values were found to be 3.48 mIU/L and 27.57 mIU/L for thyroid stimulating hormone, 0.89 ng/dL and 1.53 ng/dL for free thyroxine and 1.19 pg/mL and 2.51 pg/mL for free triidothyronine respectively. Conclusion:- In the present study the reference intervals of thyroid stimulating hormone ,free thyroxine and free triidothyronine were tried to be established and based on the results obtained , were 3.48 - 27.56 mIU/L for thyroid stimulating hormone, 0.89 - 1.53 ng/dL for free thyroxine and 1.19 - 2.51 pg/mL for free triidothyronine. It has been concluded that the result can provide us with an important clue to establish population specific reference intervals using large scale studies.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Thyroid function tests, reference intervals, screening program, Congenital hypothyroidism |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 29 Jun 2018 12:00 |
| Last Modified: | 29 Jun 2018 12:00 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6251 |
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