Godebo, Amanuel (2015) Hypoglycemic and Antihyperglycemic Effect of Leaves Extracts of Psidium Guajava in Normoglycemic and Streptozotocin-Induced Diabetic Mice. Masters thesis, Addis Ababa University.
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Abstract
Background: Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia. As the morbidity and mortality rate from diabetes is increasing in low- and middle-income countries, it is necessary to evaluate medicinal plants for their pharmacological effects to support existing drugs in treating diabetes. The present study was undertaken to evaluate the hypoglycemic and antihyperglycemic activity of leaf extracts of Psidium guajava in normoglycemic and streptozotocin-induced diabetic mice. Methods: The aqueous and ethanol extracts of Psidium guajava leaves were prepared. Swiss albino mice of either sex weighing 20-30 grams were selected for the experiments. Normal mice were grouped into eight groups to carry out hypoglycemic effect of the extracts, whereas mice that were made diabetic were grouped into nine groups to study the antihyperglycemic effect of the extracts. Diabetes was induced by Streprozotocin (STZ). Blood glucose levels were measured using glucose oxidase method. Results: The aqueous and ethanol extracts of Psidium guajava leaves lack hypoglycemic effect on normoglycemic mice. However, a significant decrease in blood glucose levels (P<0.05) was observed after administering for 21 days treatment of the aqueous and ethanolic extracts of Psidium guajava leaf to Streptozotocin-induced diabetic mice. Guava leaf extracts contain alkaloids, phenols, flavonoids, tannins and saponins that could be responsible for the observed antihyperglycemic effect. It was also observed that the extracts have shown no acute toxicity. Conclusion: The aqueous and ethanol extracts of Psidium guajava leaves are effective in lowering blood glucose level in diabetic mice, but lack hypoglycemic effect in normoglycemic mice. Further studies are warranted to elucidate possible mechanism(s) of action of the plant material.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Hypoglycemic, Antihyperglycemic, Psidium guajava, Strepotozotocin, Mice |
| Subjects: | Q Science > Q Science (General) R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 29 Jun 2018 12:08 |
| Last Modified: | 29 Jun 2018 12:08 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6257 |
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