Endrias, Asrat (2016) Total Oxidant-Antioxidant Status among Psoriatic Patients Attending at Alert Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation in which the genetic and environmental factors are involved that trigger the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have to have a consequent function in psoriasis. Aim of the study: The presented research work was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methods: A comparative cross-sectional study was undertaken with 45 clinically diagnosed psoriatic patients without any drug therapy and 45 age-sexes matched healthy controls. The severity of psoriasis was determined by Psoriasis area severity index. Out of total 45 Psoriasis patients, 22 were mild, 15 moderate and remaining 8 were severe psoriatic patients. Levels of Total Oxidant Capacity, Total Anti-oxidant Capacity and Oxidative Stress Index were measured in patients and controls. Results: The present study showed significantly (p<0.001) increased levels of serum Total Oxidant Capacity as well as Oxidative Stress Index (p<0.001) in psoriasis patients as compared to controls and positively correlated with severity and duration of the disease. Total Anti-oxidant Capacity levels were significantly (p<0.001) lower in patients than in controls and negatively correlated with severity and duration of the disease. Conclusion: These results provide some evidence regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Total Oxidant capacity, Total Antioxidant capacity, Oxidative stress index Psoriasis |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 02 Jul 2018 13:14 |
| Last Modified: | 02 Jul 2018 13:14 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6429 |
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