Burden of Smear Negative Pulmonary Tuberculosis Before and After Antibiotic Use: The Case of Four Public Health Center of Addis Ababa, Ethiopia

Mohammed, Awad (2016) Burden of Smear Negative Pulmonary Tuberculosis Before and After Antibiotic Use: The Case of Four Public Health Center of Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.

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Abstract

BACKGROUND: diagnosis of pulmonary tuberculosis in sputum smears-negative patients is challenging in today’s medical practice. As a result, Diagnosis of SNPT mostly supported on clinical and radiographic elements in our country set up. OBJECTIVE: This study was initiated to determine the burden of Smear Negative Pulmonary Tuberculosis before and after antibiotic use in selected public health centers in Addis Ababa, Ethiopia. DESIGN: A prospective cross sectional study was conducted among suspected pulmonary tuberculosis patients visiting four public health centers of Addis Ababa, Ethiopia between May 25, 2015 and September 30, 2015. METHODS: A total of 220 informed and consented patients with suspected pulmonary tuberculosis were screened for acid fact bacilli by direct smear microscopy. All smear negative morning sputum samples were further processed for culture using solid Lowenstein-Jensen medium at the St.Peter TB Specialized Hospital TB laboratory. RESULTS: 206 (93.6%) patients with suspected pulmonary tuberculosis have had a negative smear results for acid fast bacilli. 16 (7.76%) and 14 (6.8%) patients whose smears were negative for acid fast bacilli found to be positive for mycobacterium culture before and after taking broad spectrum antibiotics respectively. Abnormal chest x-ray findings were observed in 25 (54.3 %) out of 46 patients. Night sweat and weight loss have shown significantly associated with culture confirmed SNPT. CONCLUSIONS: The present study showed 92.2% smear negative pulmonary tuberculosis cases were still etiologically unexplained by culture. Therefore, there is a need to improve practice on sputum sample collection, processing and using other existing better diagnostic approaches for the diagnosis of SNPT in the Ethiopian setting to avoid mis- diagnosis of patients. Acknowledgment First of all I want to thank Almighty God to help finish this thesis paper. Then I would like to thank department of Medical Laboratory Science for accepting to do the research project and allocating advisor and other things. Then, to my advisor Kassu Desta who initiate me to work on the title at the beginning and help me in the overall preparation of this thesis paper. Then I want to gratitude St.Peter Specialized TB Hospital, especially TB lab staffs, to work on their culture facility and to collaborate with me to work the research project. Lastly all participating health center staffs and study participants, without them this paper could not happen.

Item Type:	Thesis (Masters)
Subjects:	Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Africana
Depositing User:	Vincent Mpoza
Date Deposited:	03 Jul 2018 07:27
Last Modified:	03 Jul 2018 07:27
URI:	http://thesisbank.jhia.ac.ke/id/eprint/6456

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