Belachew, Aweke Mulu (2015) Effect of Ginger Rhizome Homogenate, Ginger Rhizome Steam Distillate, and Simvastatin on Fasting Blood Glucose and Serum Lipid Profiles of Streptozotocin-Induced Diabetic Balb/C Mice. Masters thesis, Addis Ababa University.
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Abstract
Introduction: Diabetes is an increasing problem in Ethiopia, affecting up to 6.5% of Ethiopian adults. There are serious complications associated with diabetes, particularly macrovascular and microvascular complications. Controlling blood glucose significantly reduces the risk of complications of diabetes. Insulin therapy is the only current treatment for type 1 diabetes. Type 2 diabetes can be treated with insulin as well numerous oral and injectable medications. However, current diabetes treatment has disadvantages, such as drug-related hypoglycemia and high cost. Traditional medicine is used to treat diabetes across the world and is readily available and inexpensive. Ginger (Zingiber officinale) is widely consumed as a spice, and numerous studies suggest that ginger may have beneficial effects for diabetes and dyslipidemia. However, further studies are needed to evaluate these effects of ginger. Objectives: To evaluate the effects of homogenized ginger rhizome, and a steam distillate of ginger rhizome containing 25% gingerol, on blood glucose and fasting lipid profiles of streptozotocin (STZ)-induced diabetic mice and to compare these effects with those of simvastatin. Methods: Balb/c mice were randomly assigned to receive ginger rhizome homogenate, steam distillate of ginger rhizome or simvastatin treatment. Two doses of streptozotocin (33mg’kg) were given intraperitoneally a week apart to induce diabetes. Mice were treated with 2g/kg/day of ginger rhizome homogenate by oral gavage, or about 3 mL/kg/day of steam distillate of ginger rhizome by oral gavage, or 40mg/kg/day simvastatin intraperitoneally. Body weights, blood glucose and lipid profiles were measured. Results: Oral gavage with ginger rhizome homogenate caused significant blood glucose increases, whereas a steam distillate of ginger rhizome showed significant blood glucose lowering effects, in STZ-induced diabetic mice. Diabetic mice treated with ginger rhizome homogenate for 56 days showed significantly lowered serum LDL and triglyceride, and higher HDL levels compared with non-treated diabetic mice but had no significant effect on total cholesterol. The steam distillate of ginger rhizome, given by oral gavage, lowered LDL but had no significant effect on HDL, total cholesterol or triglyceride levels of STZ-diabetic mice. Simvastatin (40mg/kg) given intraperitoneally decreased blood glucose, decreased LDL and increased HDL, but had no significant effect on triglycerides and total cholesterol in STZ-diabetic mice. None of these treatments, ginger rhizome homogenate, steam distillate, or simvastatin, had a major effect on weights of diabetic mice. Conclusions: Ginger rhizome homogenate treatment exacerbated hyperglycemia in STZ-diabetic mice, but improved diabetic dyslipidemia, while a steam distillate of ginger rhizome and simvastatin each decreased fasting blood glucose and improved lipid profiles of STZ-induced diabetic mice.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 03 Jul 2018 07:31 |
| Last Modified: | 03 Jul 2018 07:31 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6460 |
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