Bacha, Aberra (2017) Effect of Ketofol Versus Propofol as an Induction Agent on Ease of Laryngeal Mask Airway Insertion Conditions and Hemodynamic Stability in Children: A Prospective Cohort Study. Masters thesis, Addis Ababa University.
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Abstract
Background: Laryngeal mask airway is a simple supraglottic device which has led to a radical change in the management of modern general anaesthesia. In the present study, we evaluated the laryngeal mask airway insertion conditions and hemodynamic changes comparing ketamine-propofol mixture (ketofol) with propofol. Objective: The objective of this study was to compare ketamine–propofol mixture (ketofol) with propofol on the ease of laryngeal mask airway insertion conditions for induction of general anaesthesia (GA).The hemodynamic effects were also looked at. Materials and Methods: In this prospective cohort study120 pediatric patients age 2 – 15 years undergoing general anesthesia with LMA for elective ophthalmic surgeries at Menelik II Hospital from Jan 25 -March, 25, 2017 were included. A six variable (mouth opening, ease of insertion, swallowing, coughing, movement and laryngospasm) three-point score was used to assess insertion conditions. LMA insertion summed score was prepared depending upon these variables. Hemodynamic variables Heart rate and mean arterial pressure were noted 1 min before induction (baseline), immediately after induction, immediately after insertion of LMA and 1,2 and 3 minute after LMA insertion. Insertion conditions were compared using Chi-square test while hemodynamic variables were compared using independent t test. Results: LMA insertion summed score was nearly similar between the two groups. Mean blood pressure and heart rate were maintained higher in ketofol group while significant drop were observed in propofol group. The time from the LMA placement to the return of spontaneous ventilation was significantly longer in propofol group (240 seconds [range =60– 360 seconds]) compared with ketofol group (180 seconds [range= 30–320 seconds]) (p= 0.005). Conclusion and Recommendations: LMA insertion condition summed score was comparable in both ketofol and propofol group. Ketofol provided equivalent LMA insertion conditions while maximizing hemodynamics and minimizing apnea time. When parameters such as LMA insertion conditions and hemodynamic stability are considered, ketofol can be used as an alternative to propofol for LMA insertion in pediatrics.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > Q Science (General) R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 03 Jul 2018 10:22 |
| Last Modified: | 03 Jul 2018 10:22 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6515 |
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