Mosisa, Balisa (2014) Isolation, Physicochemical Characterization and Evaluation of Triticum Decocum Starch as Binder and Disintegrant in Paracetamol Tablets. Masters thesis, Addis Ababa University.
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Abstract
Background: Oat is one of cereal grain which has about 10-15 species of true grasses (family Poaceae). Even though, Avena sativa L (common oat) is the most important one among cultivated oat in most parts of the globe; four other species are grown as crops of minor or regional importance of which Triticum decocum which is cultivated in Ethiopia is one. Triticum decocum is a half-weed, half-crop with erect stems which are small and fairly stiff with equilateral panicles and medium size, just very drooping. Objective: The main purpose of current work is to study the physicochemical properties of Triticum decocum starch, and evaluate its binding and disintegrating properties in paracetamol tablets. Statement of the problem: With the recent global renewed interest of natural polymers for industrial consumptions, the demand for the starch is expected to hit 230 million metric tons per year by 2015 globally. Current starch demand of Ethiopia which is more than 400 tons per year is imported from other countries. The need is escalating with industrial advancement. To cope up with these demands, potential endogenous sources of starches including, Triticum decocum starch, should be considered if being economical and sustainable supply is anticipated. Methods: Different methods previously described elsewhere were used to achieve the above objective with slight modification as its importance. Result and Discussion: The proximate composition of the starch on dry weight basis was found to be 0.23 % ash, 0.26 % protein, 1.54 % fat and 56.31 % starch. The total amylose content was 28.4 % with 20.11% apparent amylose and 29.19% lipid complexed amylose. SEM showed oval and spherical shaped granules. The particle size distributions of the starch showed monomodal normal particle size distribution with the average volumetric particle diameters being about 23.03μm, and specific surface area 0.7186 m2/g. XRD showed a pattern that is typical of A-type with a distinctive maximum peak at around 17° 2θ. At all relative humidities, its water sorption properties resemble that of Zea mays starch. It has unique swelling power and solubility in water at different temperature. Viscosity curves of 10% starch paste showed a peak viscosity of 1926cP. Its cold paste viscosity and hot paste viscosity were 4236cP and 1720 cP, respectively. The breakdown and set back of Triticum decocum starch were 206 and 2647cP, respectively. II Powder mix of the starch with paracetamol has poor flow and compressibility properties. But after wet granulation, the granules have good flow and compressibility properties. Tablet crushing strengths, friabilities, disintegration times and dissolution profiles results had shown promising results. Conclusion and Recommendation Based on the above results, Triticum decocum starch can be used both as a binding agent and disintegrant. It has a better binding ability than Zea mays starch, giving tablets of higher strength and less friability. However, tablets containing Triticum decocum starch disintegrate slightly more slowly. Different methods of extraction, modifications, and other use evaluations had better conducted on the starch.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Triticum decocum, physico-chemical properties, chemical composition, flow and compressibility |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 04 Jul 2018 07:16 |
| Last Modified: | 04 Jul 2018 07:16 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6523 |
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