Teklemichael, Hiyab (2017) Assessment of Incidence and Treatment Outcome of Septic Shock among Patients Admitted to Adult Intensive Care Unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Introduction Septic shock is a major healthcare problem, affecting millions of people around the world each year, killing one in four and increasing in incidence. In most developed countries, the incidence of Septic shock has been identified as between 50 and 100 cases per 100,000 people in the population. The mortality rate from severe sepsis in the developed countries has been estimated as being between 28 and 50%, ranging from 15% in patients with sepsis and up to 40-50% in patients with septic shock with multi-organ dysfunction syndrome (MODS) Objective The study aims to explore the incidence and the factors associated with outcome among patients with septic shock admitted to the intensive care unit, TASH, Addis Ababa, Ethiopia. Method A retrospective cross-sectional study was carried out at intensive care unit of our hospital. This study included all patients with septic shock admitted to adult ICU of TASH during Jan 2014- Dec 2017. Data was collected using a structured checklist and statistical analysis was done using SPSS version 21. Regression model was applied to identify the factors contributing to the outcome of septic shock. P-value less than 0.05 were considered statistically significant. Results Of 820 admissions, 115 (14%) patients had septic shock. Majority (60%) was female and the mean age was 47.9+16.5 years. The most common sites of infection were the respiratory tract infection (54.8%) followed by urethral tract infection (14.8%), Gram-negative bacteria, particularly Escherichia coli (4.3%) and Klebsiella pneumonia (3%), were the major infecting micro-organisms. All patients have received antibiotic and fluid therapy. 23.5% patients started treatment within the first hr. of ICU stay and the overall 28-day mortality rate was 58.3%. Conclusion The study revealed that septic shock is a frequent cause of ICU admission with a high mortality rate. This can be explained by the fact that septic shock patients have more comorbidity, a worst previous state of health and requires more life support therapies. Therefore early identification of high risk population, implementation of appropriate treatment and the design of future clinical studies are crucial to improve the outcome of septic shock.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 04 Jul 2018 08:37 |
| Last Modified: | 04 Jul 2018 08:37 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6562 |
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