Jima, Bethelihem (2016) Prevalence and Risk Factors of Renal Impairment among Rheumatoid Arthritis Patients Attending Outpatient Department of Tikur Anbessa Specialized Hospital ,Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: The global burden of chronic degenerative disease is increasing worldwide. Most developing countries have dual burden with infectious and non-infectious diseases. Kidney Disease (KD) is a long term health condition and defined as the gradual loss of body and renal function, death over time. Renal abnormalities were quite prevalent in Rheumatoid Arthritis (RA) patients and there was significant increase of renal derangement with duration of disease and severity of disease activity. Objective: To determine the prevalence of renal impairment and to identify associated risk factors on Rheumatoid Arthritis Patients at Tikur Anbessa Specialized Hospital(TASH). Methods: A hospital based cross sectional study conducted from July 2015 to January 2016 at Tikur Anbessa Specialized Hospital. The study participants were all patients with a diagnosis of RA on follow up at Tikur Anbessa Specialized Hospital during the study period and having a baseline data. The participants interviewed by trained data collectors using pretested and structured questionnaires. Blood sample was collected for assessment of Urea and Creatinine. Urine sample was also collected for protein and blood detection. Serum Creatinine was analyzed by an automated biochemistry machine Mindray 200BS.Urine protein and blood was detected by chemical test. Finally data was entered and analyzed through SPSS version 20 computer software packages. Result: Out of 219 RA patients, 49(22.4%) had renal impairment. Serum Creatinine level in mg/dl of the patients were with mean and Standard Deviation (SD) of (1.67,±0.47SD) with Adjusted odd ratio(AOR)and(95%CI):14.07(5.09,38.91), Mean (±SD) age of the participants was 43.82 (± 14.03) years and about 75.3% were females. Protienuria 44 (20.1%) with AOR (95%CI): 1.93(1.68, 5.58) and Body Mass Index (BMI) above 25 with AOR (95%CI): 0.1(0.02, 0.45). showed significant association with the prevalence of renal impairment. Conclusion: The study revealed that the prevalence of renal impairment in patients’ with RA is high. Screening for renal impairment for patients with RA will be very helpful to peak KD at earlier stage.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 04 Jul 2018 12:14 |
| Last Modified: | 04 Jul 2018 12:14 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6620 |
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