Insulin Resistance and Dyslipidemia in Type 2Diabetic Patients: A Cross-Sectional Study at the Diabetic Clinic of Tikur Anbessa Specialized Teaching Hospital

Mekonnen, Betelhem Tefera (2015) Insulin Resistance and Dyslipidemia in Type 2Diabetic Patients: A Cross-Sectional Study at the Diabetic Clinic of Tikur Anbessa Specialized Teaching Hospital. Masters thesis, Addis Ababa University.

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Abstract

Background: Type 2 diabetes is a major non-communicable disease with an increasing prevalence in Ethiopia and worldwide. About 2% of Ethiopians are reported to have type 2 diabetes, but this may be an underestimate, due to a paucity of studies on diabetes epidemiology in Ethiopia. Objective: Assessment of insulin resistance and dyslipidemia in type 2 diabetic patients attending diabetic clinic of the Tikur Anbessa Hospital, Addis Ababa. Methods: This study was carried out on 106 type 2 diabetic patients attending Tikur Anbessa Specialized Hospital Diabetic Clinic. Fasting blood glucose, serum lipid panels, serum insulin concentrations, Apo lipoprotein A-1 and Apo lipoprotein B were measured in diabetics who were taking oral medications. Patients taking insulin were excluded from the study. Insulin resistance was measured by calculating HOMA-IR for each patient. Blood pressure, body mass index (BMI), waist circumference and smoking status were also determined. Result: Most patients (80%) had poorly controlled fasting blood glucose (>126 mg/dL), and this was similar for males and females. Serum triglycerides were abnormally high in 58.7% of patients, LDL-cholesterol levels were elevated above 100 mg/dL in 50% of patients, and serum HDL-c levels were abnormally low in 76.9 % of patients.88.6% of the diabetic patients had showed significant insulin resistance (P<0.05), indicated by an elevated HOMA-IR index (>3.0). Two third of the diabetic patients showed normal blood pressure. Furthermore, sixteen of the 106 patients were cigarette smokers and smokers over 40 years old with diabetes had substantial cardiovascular risks as determined by their Framingham cardiovascular risk score. Conclusion: These results emphasize the need for improvedprograms for diabetes screening, prevention and care in Ethiopia. The biochemical and medical significance of the results are discussed.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Type2Diabetes,Insulin Resistance, Dyslipidemia, HOMA-IR, Apolipoprotine
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Africana
Depositing User:	Vincent Mpoza
Date Deposited:	04 Jul 2018 12:50
Last Modified:	04 Jul 2018 12:50
URI:	http://thesisbank.jhia.ac.ke/id/eprint/6625

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