Bogale, Kassahun (2017) Outcome of Patients with Acute Coronary Syndrome Admitted to Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Worldwide, coronary artery disease (CAD) is the single most frequent cause of death. Over seven million people every year die from CAD, accounting for 12.8% of all deaths. The objective of this study was to assess the treatment outcome and associated factors for Acute Coronary Syndrome (ACS) patients admitted at Tikur Anbessa Specialized Hospital (TASH). A retrospective cross sectional study was conducted by chart review of patients who were discharged with a diagnosis of ACS during the period January 1, 2012 to December 31, 2014. Of 124 ACS patients who were admitted during the three years period, 90(72.6%) were diagnosed as STEMI. The mean age was 56.3 ±13.7 years. The average length of hospital stay was 9.77± 6.42 days. The average time from onset of ACS symptoms to presentation in the emergency department was 3.8 days (91.7 hours). In about 76 (61.3%) patients hypertension was the leading risk factor for development of ACS. 36.4% of ACS patients in TASH were either Killip class III or IV. Biomarkers were measured for 118(95.2%) patients. 79.2% of patients had ejection fraction (EF) of less than 40% and 29.2% had less than 30%. In-hospital medications include loading dose of aspirin (79%), anti-coagulants (77.4%), beta-blockers (88.1%), statins (85.5%), morphine (12.9%), and nitrates (35.5%). The in-hospital mortality was 27.4%. Predictors of inhospital mortality in TASH included age (P=0.042), time from symptom onset to presentation (P=0.001), previous history of hypertension (P=0.025), being Killip class III and IV (P=0.001), and STEMI diagnosis (P=0.005). Hence, based on the results the medical management of ACS patients in TASH was in line with the recommendations of international guidelines but inhospital mortality was very high (27.4%).
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Acute Coronary Syndrome, Outcome, In-Hospital Mortality |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 04 Jul 2018 14:57 |
| Last Modified: | 04 Jul 2018 14:57 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6641 |
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