Evaluation and Comparison of Serum Lipid Profiles between Newly Diagnosed and Tamoxifen Treated Breast Cancer Female Patients Attending the Oncology Clinic at Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia

Birhan, Bihonegn (2017) Evaluation and Comparison of Serum Lipid Profiles between Newly Diagnosed and Tamoxifen Treated Breast Cancer Female Patients Attending the Oncology Clinic at Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.

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Abstract

Background: Breast cancer is the most common cancer in women worldwide and the second most common cancer overall. It is the leading cause of cancer death in less developed countries including Ethiopia. Dyslipidemia in breast cancer patients has long been considered as the risk factor for cardiovascular diseases. Estrogen induces hyperlipidemia through its multiple effects on lipid metabolism. Tamoxifen used for breast cancer treatment, is essentially anti-estrogenic, however, currently, it has been suggested that its estrogenic activity is mainly responsible for the changes in lipid parameters. Because marked hyperlipidemia is a potent risk factor for life-threatening acute pancreatitis and arteriosclerosis, plasma lipid levels should be tested periodically in breast cancer patients. However, detection of lipid profiles in newly diagnosed and tamoxifen treated breast cancer women have not been investigated yet in our country, Ethiopia. Objective: Therefore, the aim of this study was to evaluate and compare serum lipid profiles between newly diagnosed and tamoxifen treated breast cancer women attending the oncology clinic at TASH. Patients and methods: Comparative cross-sectional study design was used to determine fasting serum lipid profiles in newly diagnosed and tamoxifen treated women with breast cancer in the oncology clinic of TASH. Convenience sampling method was applied to recruit study subjects and 52 breast cancer women treated with tamoxifen for three months and above and 51 new medically diagnosed breast cancer women without treatment were included and serum lipid parameters (TG, TC, HDL-C, and LDL-C) were measured. Result: In breast cancer women receiving tamoxifen, the mean serum TC and LDL-C levels were significantly reduced but TG levels were insignificantly decreased accompanied by the elevation of HDL-C though it was insignificant as compared to those women with no treatment. Conclusion: lipid profile is significantly improved upon tamoxifen treatment and this confirms that tamoxifen has cardio protective roles in lipid metabolism.

Item Type:	Thesis (Masters)
Subjects:	Q Science > Q Science (General) R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine
Divisions:	Africana
Depositing User:	Vincent Mpoza
Date Deposited:	04 Jul 2018 14:59
Last Modified:	04 Jul 2018 14:59
URI:	http://thesisbank.jhia.ac.ke/id/eprint/6647

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