Mamuye, Binyam (2016) Assessements of Protein Energy Wasting in Patients with Chronic Kidney Disease, Attending Renal Unit at Tikur Anbesa Specialized Hospital. Masters thesis, Addis Ababa University.
![[img]](http://thesisbank.jhia.ac.ke/style/images/fileicons/application_pdf.png) |
PDF (Assessements of Protein Energy Wasting in Patients With Chronic Kidney Disease, Attending Renal Unit at Tikur Anbesa Specialized Hospital)
Biniam Mamuye.pdf - Accepted Version Restricted to Repository staff only Download (437kB) | Request a copy |
Abstract
Background: - Protein energy wasting (PEW) is highly prevalent in patients with chronic kidney disease (CKD) and is a strong predictor of morbidity and mortality. Although data concerning the prevalence of PEW in CKD are scarce in Ethiopia, it is hypothesized that there would be comparable numbers of CKD patients with PEW in the country. Objectives: - The aim of the study was to assess protein energy wasting in patients with chronic kidney disease attending Renal unit at Tikur Anbesa Specialized Hospital. Methodology: - A cross sectional study design was conducted on 125 subjects at Tikur Anbessa Specialized Hospital. Out of the total, 85 were CKD patients and 40 were controls. Based on their GFR values, CKD patients were further divided in to three groups. Group-I (n= 39) (GFR 30-60 ml/min/1.73m2), Group-II (n=28) (GFR 15-29 ml/min/1.73m2) and Group-III (n=19) (GFR <15 ml/min/1.73m2 .Data were presented as mean ± SD. Data entry and analysis was performed using SPSS version 20 statistical software. A level of p<0.05 was considered statistically significant. Result: - The prevalence of protein energy wasting in CKD patients was found to be20% (17/85). There was significant lowering of serum albumin, BMI and mid arm muscle circumference (MAMC) among all groups of CKD patients when compared with controls p<0.05.Group III patients had maximum percentage of MAMC reduction >10% >6 months, and lowest BMI values < 18.5 kg/m² (42.1%, 63.2%) respectively. Maximum percentage of cases having weight loss > 10% > 6 months (47.4%) and s-albumin below the reference of 3.8g/dl (42.1%) were also in Group-III patients. GFR was found to be strongly correlated with s-albumin, BMI, and MAMC; while negatively correlated with unintentional weight loss. Conclusion: The prevalence of protein energy wasting increased with advancing stage of CKD. Biochemical and anthropometric parameters deteriorated as kidney function decreased.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Chronic kidney disease, Protein energy wasting, Mid Arm Muscle Circumference, Body mass index, Unintentional weight loss, serum albumin |
| Subjects: | Q Science > Q Science (General) Q Science > QP Physiology R Medicine > R Medicine (General) |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 04 Jul 2018 15:42 |
| Last Modified: | 04 Jul 2018 15:42 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6656 |
Actions (login required)
 |
View Item |