Yirdaw, Ketsela (2016) Postsurgical Assessment of Serum Interleukin-6 and C-reactive protein in Breast Cancer Patients before Receiving Adjuvant Chemotherapy. Masters thesis, Addis Ababa University.
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Abstract
Background: Breast cancer is one of the most common cancers in females. Several studies have shown proinflammatory biomarkers can facilitate tumor growth and metastasis by altering tumor cell biology and activating stromal cells in the tumor microenvironment. They have been also associated with poor survival of breast cancer patients. Objective: The aim of this study was to evaluate postsurgical serum interleukin 6 and C reactive protein in breast cancer patients before receiving chemotherapy in Tikur Anbessa specialized teaching hospital, Ethiopia. Methodology: A hospital based cross sectional study design and a convenient nonprobability sampling technique were applied in this study. Forty-four breast cancer patients visiting oncology chemotherapy unit were identified for the study and were subjected to assessment. Serum interleukin-6 and c –reactive protein values were measured before initiation of adjuvant chemotherapy in breast cancer patients using an ElectroChemiLuminescencetechnology (ELC) assay technique and immunoturbidimetric respectively. Result: A total of 44 cases were included in the study. The median age was 42 years, the majority of patients had invasive ductal carcinoma, and did present with positive nodes involvement. Postsurgical elevated levels of serum CRP and IL-6 were observed in most of the patients. Progress in breast cancer staging were associated with increases in serum IL-6. IL-6 level correlated with stage (P < 0.026), CRP has borderline correlation with stage (p = 0.05). However, IL-6 and CRP have shown insignificance correlation with tumor size and lymph node involvement. Serum IL-6 levels were correlated positively with CRP levels (rho = 0.530, p < 0.01). Conclusion: These results suggest that proinflammatory status of the breast cancer patient have high values of interleukin-6 and C– reactive protein. Progressive elevation of serum interleukin 6 observed as stage of cancer advanced.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | interleukin-6, C - reactive protein, breast cancer, proinflammatory |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 04 Oct 2018 12:19 |
| Last Modified: | 04 Oct 2018 12:19 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6726 |
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