Hassen, Makida Kemal (2017) Schistosoma Mansoni Infection and Response Rate for Praziquantel in Pre-School Aged Children Attending ERER Health Center Somali Regional State, Eastern Ethiopia. Masters thesis, Addis Ababa University.
![[img]](http://thesisbank.jhia.ac.ke/style/images/fileicons/application_pdf.png) |
PDF (Schistosoma Mansoni Infection and Response Rate for Praziquantel in Pre-School Aged Children Attending ERER Health Center Somali Regional State, Eastern Ethiopia)
Makida Kemal Hassen.pdf - Accepted Version Restricted to Repository staff only Download (955kB) | Request a copy |
Abstract
Background: Intestinal schistosomiasis is one of the most widespread parasitic infections in tropical and subtropical countries. In sub-Saharan Africa, the recommended strategy to control schistosomiasis is preventive chemotherapy. Though World Health Organization (WHO) recommends praziquantel for the control and treatment of schistosomiasis, Pre-school aged children (PSAC) are excluded from population treatment programs mainly due to paucity of data on response rate. Objective: The aim of this study is to assess the magnitude of Schistosoma mansoni infection and response rate to praziquantel treatment in pre-school aged children (≤ 5 years of age). Methods: Facility based prospective study was conducted between April to June 2016 at Erer Health Center, Eastern Ethiopia. Stool sample was collected and examined with double Kato-Katz for two consecutive days from children attending the health center and repeated after four weeks of post-treatment from those who had been infected with S. mansoni. Response rate of praziquentel was assessed after treatment with praziquantel at a single dose of 40mg/kg given by health professionals at health center. Interview was used to assess socio demographic background and clinical data. Data analysis was performed using SPSS version 20. Bivariate and multivariate analysis was performed to test statistical association of dependent and independent variables. Results: The prevalence of S. mansoni among PSAC was 25%. The result showed a 96.4% cure rate and 99.4% egg reduction rate four weeks post treatment resulting in good response rate. Age of children and frequency of taking children to the river was significantly associated with S. mansoni infection. The more often children were taken to river during fetching water also associated to S. mansoni infection with (AOR=3.86). Conclusion: This study reveals that treatment of S. mansoni infection with praziquantel shows good response in pre-school children. Thus, it is recommended that FMOH should include pre-school children in S. mansoni endemic areas in mass de-worming campaign through administering praziquantel.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Schistosoma- mansoni, Praziquantel, response rate, pre-school children |
| Subjects: | Q Science > QR Microbiology Q Science > QR Microbiology > QR180 Immunology R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 22 Oct 2018 12:02 |
| Last Modified: | 22 Oct 2018 12:02 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/6983 |
Actions (login required)
 |
View Item |