Belete, Engdawork (2017) Assessment of Serum Tryptase Activity among Acute and Chronic Myeloid Leukemia Patients visiting Hematology- Oncology clinic at Tikur Anbessa Specialized Hospital, and Comparison with Healthy Controls. Masters thesis, Addis Ababa University.
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PDF (Effect of Propofol Versus Thiopentone With Lignocaine Spray for Laryngeal Mask Airway Insertion, at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia,2017 : A Prospective Cohort Study)
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Abstract
Background: Insertion of laryngeal mask airway (LMA) requires an adequate depth of anesthesia. The choice of the intravenous induction agent was influence the insertion conditions depending on its ability of optimize the pharyngeal, laryngeal reflexes and hemodynamic stability. Objectives: This study aims to compare the effect of Thiopentone with 10% topical Lignocaine spray(TL) and propofol(P) on hemodynamic change and response condition during LMA insertion on patients age above 10 years who was undergoing elective surgery at Tikur Anbessa Specialized Hospital from January 20/2017 to April 20/2017. Methods: Study 84 participant followed in prospective cohort study, who fulfills inclusion criteria in to either TL or P based on induction type of study drugs. Data collector record baseline, after induction and LMA insertion (MAP and HR), insertion response and apneic time and dates analyzed using SPSS 20 with 95% CI, unpaired student’s t-test to continuous outcome variables, chi-square test for categorical and finally results presented as Mean ± SD and percentage. P < 0.05 was considered as statistically significant difference. Result: The comparison of data showed that reduction mean arterial blood pressure (MAP) of P group compare with thiopentone with 10% topical lignocaine group within 10 mint Mean ± SD at 1 mint after induction (74.8± 4.73vs81.8 ±5.6)p <0.001, at 1 mint after LMA insertion (78.4±5.5 vs 81.8±5.6)p<0.001), at 5 mint (80.6±4.6 vs 84±5.4)p<0.002 and at10 mint(82.5±4.3 vs 85.6±4.6),p<0.03 .There was no statistically significant differences regarding the HR change and insertion conditions between the two groups(P > 0.05).Apneic time was prolonged in P group compare to TL group (138 ±45.8 vs 85±13.8) seconds, p < 0.001. Compared the two groups on cost inquiry TL group per case 27 ET Birr cost reduced than propofol group. Conclusion and recommendation: Thiopentone with 10% topical Lignocaine is alternative for insertion of LMA to propofol, with better hemodynamic stability and cost effectiveness. We recommend that use of TL induction of anesthesia for LMA insertion age above 10 years.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Topical lignocaine, Propofol, Thiopentone, Insertion Condition, Elective Surgery |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 26 Oct 2018 14:27 |
| Last Modified: | 26 Oct 2018 14:27 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7068 |
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