Mitiku, Enkosilassie (2015) Bacteriological Profile and Antibiotic Susceptibility Pattern in Urinary Tract Infection Suspected Pediatricpatients at Hawassa Referral Hospital, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Urinary tract infection (UTI) is a common childhood infection in the Tropics, which causes significant illness and at young age can lead to renal injury and scarring, and ultimately leads to end stage renal disease in adulthood. Knowledge of the childhood etiology of UTIs and their antimicrobial susceptibility patterns in specific geographical locations may aid clinicians in choosing the appropriate antimicrobial empirical treatment. Objective: To determine prevalence, common bacterial microorganisms and their antibiotic susceptibility pattern in UTI suspected pediatric patients at HURH, Ethiopia. Methodology: A cross sectional study was carried out from February to September 2015on a total of 334 UTI suspected pediatric patients that attendedat HURH, Ethiopia. Demographic data were collected using a structured questionnaire. Mid-stream/urine bag /catheterized 3-5ml of urine samplewas done laboratory urinalysis included semi-automated dipstick and microscopic examination, then sent to the hospital microbiology laboratory within 30 minuteand inoculated ontoCystine Lactose Electrolyte Deficient medium (CLED), Blood agar plate(BAP) and MacConkey agar for 24hr at 370c. Pure isolates of bacterialpathogen were characterized by colony morphology, gram-stain, and standardbiochemical procedures. A standard method of agar disc diffusion susceptibility testingmethod was used to determine susceptibility patterns of the isolates.The data was analyzed by SPSS version 16. Results: 334 children fulfilled the eligibility criteria and were enrolled into the study. Overall prevalence of UTI (growth of ≥105CFU/mL of a urinary tract pathogen) was 32% (95% confidence interval [CI]:(27.0,36.8). Higher prevalence occurred in rural (20.8%; 95% CI: 1.58, 4.25), uncircumcised boys (11.5%; 95% CI: 1.76, 10.9), and those who had admitted (27.5%; 95%CI: 1.56, 4.73), malnourished (72.5%; 95% CI: 4.18, 15.17), Severe UTI (52.5%; 95% CI: 1.5,5.8). Escherichia Coli was the most common organism accounting for 43%, followed by Klebsiella spp 28%.S.aureos was isolated from the males’ only. Nitrofurantoin was found to have the highest sensitivity of 95.65%. Highest degree of resistance was noticed with Ampcillin and co-trimoxazol. Conclusion: almost 1/3 of pediatric patients had UTI. Escherichia coliwas the most frequent etiologic agent followed by Klebsiella species being the second most common. Clinician should prefer Nitrofurantion for treatment of UTI in greater than one month of pediatric patients.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Bacterial profile, Antibiotic susceptibility, Children, Urinary tract infection |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 29 Oct 2018 13:23 |
| Last Modified: | 29 Oct 2018 13:23 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7070 |
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