Assefa, Esete (2016) Sero-Burden of Rubella Virus and Associated Risk Factors among Pregnant Women Attending ANC at Selected Hospitals in Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Rubella is a contagious viral respiratory tract infection transmitted via airborne droplets. The virus in pregnant women causes miscarriage or stillbirth and/or serious birth defects and chronic diseases collectively called congenital rubella syndrome (CRS). The risk of congenital defects following maternal rubella infection reaches up to 90%.Worldwide it is estimated that more than 110,000 infants are born with congenital rubella syndrome each year. Most of these cases occur in developing countries that have not yet introduced rubella vaccine. There are no recent studies conducted to assess the burden of rubella infection on pregnant women and CRS in Ethiopia. Objective: To determine the sero-burden of rubella immunity and associated risk factors among pregnant women attending anti-natal care center of Mahatma Gandhi Memorial Hospital and Betsegah Mother and Children hospital in Addis Ababa. Method: A hospital – based, cross-sectional stdy was employed between March to June, 2016.A 422 pregnant women, were enrolled and data were collected using pretested questionnaires. Left over serum samples were collected and analyzed for anti-rubella Ig G and Ig M antibody using commercial Enzygnost® Anti-Rubella Virus /Ig G and Ig M ELISA test kits by following standard procedure. Data were analyzed using Epi-Info version 3.4 and SPSS version 20 software. Result: Of the 422 pregnant women tested for Anti-Rubella Ig G, 405(96.0%) were positive and out of these 341(80.8%) were immunized for rubella virus by natural infection. About 11(2.6%) of pregnant women were positive for Anti-Rubella Ig M, and 11(2.7%) pregnant women were positive for both Anti-Rubella Ig G and Ig M antibody. Overall, 11(2.7%) of the women were susceptible to Rubella infection, 5(45.5%) out of 11 in the first trimester of gestation was probably infectious to their fetus. Conclusion: The burden of rubella virus Ig G in pregnant women in study area was very high. This was in agreement with what has been found in other African countries where no rubella vaccinations are in place. Hence, screening of pregnant women for CRS is essential and initiation of rubella vaccination is urgently required.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Burden, CRS, Rubella, IgG, IgM |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 29 Oct 2018 14:35 |
| Last Modified: | 29 Oct 2018 14:35 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7098 |
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