Evaluation of the Efficacy of Artemether Lumefantrine (Al) in Patients with Uncomplicated Plasmodium Falciparum Malaria in Gende Wuha Health Center , North West Ethiopia

Wudneh, Feven (2015) Evaluation of the Efficacy of Artemether Lumefantrine (Al) in Patients with Uncomplicated Plasmodium Falciparum Malaria in Gende Wuha Health Center , North West Ethiopia. Masters thesis, Addis Ababa University.

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Abstract

Background: Most malaria control strategies depend on safe and effective drugs, although, drug resistance is the most serious problem in achieving control of malaria. Artemether/Lumefantrine (coartum®) has been used as a first-line treatment for uncomplicated Plasmodium falciparum infection since 2004 in Ethiopia. The spread of Plasmodium falciparum resistance to almost all available affordable mono-therapy, in many malaria endemic regions, is a serious impediment on malaria control. As a result there is a need to a periodic evaluation of efficacy of antimalarial drugs. Objective: The aim of this study was to evaluate the efficacy and safety of Coartem® for the treatment of uncomplicated Plasmodium falciparum infections in patients attending Gende Wuha Health Center Gondar Zone, North-West Ethiopia. Method: One arm prospective in vivo evaluation of the efficacy of artemether/lumefantrine (AL) was conducted in patients with uncomplicated Plasmodium falciparum infection. Standard six dose regimen of AL was given twice daily for 3 days under supervision and clinical and parasitological responses during a 28 day follow-up period were assessed using a standardized drug efficacy record form, on days 0, 1 ,2, 3, 7, 14, 21, 28 and adverse drug events as well as Hgb changes were also investigated. Result: A total of 81 P. falciparom mono infected patients were included in the study, majority 82.4% were males. Overall, the 28-day clinical and parasitological cure rate was 98.8% (95% CI=93.3-100%). The mean temperature and parasite count at enrollment were 37.9°C and 13,441.6rings/μL, respectively. Gametocytes were detected in 4.4% of the study participants on the day of inclusion and the mean hemoglobin level was 13.7 g/dl. Arthemesnin based combination therapy treatment rapidly cleared parasitaemia and fever by day three and complete gametocyte clearance was obtained on day 21. Insignificant hemoglobin recovery was observed among patients with adequate clinical and parasitological response. There was no severe adverse side-effects were observed among these patients. Conclusion: Artemether Lumefantrine was efficacious for the treatment of uncomplicated Plasmodium falciparum malaria in Gende Wuha town.

Item Type: Thesis (Masters)
Uncontrolled Keywords: P. falciparum, Coartem, ACT, Efficacy, Gende Wuha, Ethiopia
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR180 Immunology
Divisions: Africana
Depositing User: Vincent Mpoza
Date Deposited: 31 Oct 2018 10:43
Last Modified: 31 Oct 2018 10:43
URI: http://thesisbank.jhia.ac.ke/id/eprint/7200

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