Mulatu, Fikerte (2017) Antibiotic Susceptibility Pattern of Neisseria Meningitides Isolates from Asymptomatic Carriers in Gurage zone, Southern Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Neisseria meningitides represents a pathogen of great public health importance in both developed and developing countries. Resistance to some antimicrobial agents used either for therapy of invasive infections or for prophylaxis of case contacts has long been recognized. However, there is a limited data in relation with the antimicrobial resistance pattern of Neisseria meningitides in Ethiopia. Therefore; the aim of this study was to assess drug susceptibility pattern of Neisseria meningitides isolates from asymptomatic carrierers of all age groups at Meskan and Mareko Districts, Gurage Zone, Southern Nations, Nationalities and Peoples Regional State Ethiopia. Methods: Cross-sectional study was conducted on 187 Neisseria meningitides isolates obtained from MenAfricar project.A total of 4110 study participants from Meskan and Mareko Districts, Gurage Zone, Southern Nations, Nationalities and Peoples Regional State, Ethiopia were screened for Neisseria meningitides by the project. Antimicrobial susceptibility test (AST) was done on stored Neisseria meningitides isolates.The activity of ten antimicrobial agents used for treatment and prophylaxis of meningococcal disease was investigated. The AST was performed for Neisseria meningitides isolates according to the criteria of the CLSI guide line by disk diffusion method. Data was analysed by using SPSS version 20.0 software. Results: From 187 Neisseria meningitides isolates 8(4.28%) were serogroup X, 24(12.83%) were serogroup Y, 1(0.53%) was serogroup W135 and 154(82.35%) were non determinant (ND). Resistance for Cotrimoxazol was high accounting 116(62%) followed by Ciprofloxacine 112(60%), Cefotaxime 26(14%), Ceftriaxone 24(13%) , Meropenenem 21(11%) , Minocycline 15(8%), Rifampine 14(7.5%), Azithromycine 10(5%), Chloramphenicol 7(4%),Levofloxacin 6(3%) . 102(54.5%) isolates were resistance for more than one drug. Conclusions: An antimicrobial resistance for Neisseria meningitides isolates from asymptomatic carriers for the present study is high. Continued surveillance of meningococci for antimicrobial resistance is necessary to monitor early detection of changes in susceptibility patterns that might affect recommendations for chemoprophylaxis and treatment.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Neisseria meningitides, serogroups, sensitivity pattern, drug resistance |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 31 Oct 2018 10:08 |
| Last Modified: | 31 Oct 2018 10:08 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7202 |
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