Welde, Mengistu (2017) Antilipidemic Properties of Calpurnia Aurea Leaf Extract on High Fat Diet Induced Hyperlipidemia Male Albino Wistar Rats. Masters thesis, Addis Ababa University.
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Abstract
Introduction: Hyperlipidemia is an elevation of the plasma lipids such as triglycerides, cholesterols, cholesterol esters, phospholipids and/or plasma lipoproteins including very low density lipoprotein and low density lipoprotein, and reduced in the circulating high-density lipoprotein levels. It is associated with an increased risk of coronary heart disease such as atherosclerosis and myocardial infarction. Objective: To investigate the antilipidemic properties of hydromethanolic extract of Calpurnia aurea leafs against high fat diet induced hyperlipidemic male albino wistar rats. Methods: Thirty albino Wistar rats’ 60-75days old and weight of 150- 200 grams were divided randomly in to six groups of five each. Group I served as normal control, group II received high fat diet (48.8% fat w/w) containing lard made from beef fat and mixed with hydrogenated vegetable oil, group III received high fat diet supplement with 3.5 mg/kg/day atorvastatin as standard control and the remaining three groups IV, V and VI received high fat diet along with hydromethanolc extract of Calpurnia aurea at (200,300 and 400) mg/kg/day respectively for 60 days. Food intake, Body weight, body mass index, serum lipid profiles and liver histopathology were assessed. Results: The result of this study revealed hydromethanolic extract of Calpurnia aurea /HMECA have dose dependent antilipidemic activities. Calpurnia aurea treatment of 400mg/kg caused a significant lowering of (p < 0.05) of serum LDL from 28.53±12.2 mg/dl to 9.70 ± 5.77 mg/dL; the serum Cholesterol level from 92.00± 13.0 mg/dl to 60.33± 8.60 mg/dl; and the serum triglyceride leve1from 71.83 ± 13.0 mg/dl to 84.73±19.4 mg/dl and on the other hand for the same dose it had significant elevated serum HDL levels from 11.66 ±1.23 mg/dl to 29.66± 1.52 mg/dl. At the medium dose of 300mg /kg it was not effective as 400mg /kg and at the minimal dose of 200mg/kg brought numerical difference not statisticaly significant among the serum lipid profile. Conclusion: These observations suggest that HMECA has a dose dependent antihyperlipidemic effect against high fat diet induced hyperlipidemia. The molecular mechanism of antilipidemic activities of this drug need to be studied.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Calpurnia aurea, High fat diet, Hyperlipidemia, Lipid profile, Atorovastatin |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 31 Oct 2018 10:02 |
| Last Modified: | 31 Oct 2018 10:02 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7208 |
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