Antilipidemic Properties of Calpurnia Aurea Leaf Extract on High Fat Diet Induced Hyperlipidemia Male Albino Wistar Rats

Welde, Mengistu (2017) Antilipidemic Properties of Calpurnia Aurea Leaf Extract on High Fat Diet Induced Hyperlipidemia Male Albino Wistar Rats. Masters thesis, Addis Ababa University.

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Abstract

Introduction: Hyperlipidemia is an elevation of the plasma lipids such as triglycerides, cholesterols, cholesterol esters, phospholipids and/or plasma lipoproteins including very low density lipoprotein and low density lipoprotein, and reduced in the circulating high-density lipoprotein levels. It is associated with an increased risk of coronary heart disease such as atherosclerosis and myocardial infarction. Objective: To investigate the antilipidemic properties of hydromethanolic extract of Calpurnia aurea leafs against high fat diet induced hyperlipidemic male albino wistar rats. Methods: Thirty albino Wistar rats’ 60-75days old and weight of 150- 200 grams were divided randomly in to six groups of five each. Group I served as normal control, group II received high fat diet (48.8% fat w/w) containing lard made from beef fat and mixed with hydrogenated vegetable oil, group III received high fat diet supplement with 3.5 mg/kg/day atorvastatin as standard control and the remaining three groups IV, V and VI received high fat diet along with hydromethanolc extract of Calpurnia aurea at (200,300 and 400) mg/kg/day respectively for 60 days. Food intake, Body weight, body mass index, serum lipid profiles and liver histopathology were assessed. Results: The result of this study revealed hydromethanolic extract of Calpurnia aurea /HMECA have dose dependent antilipidemic activities. Calpurnia aurea treatment of 400mg/kg caused a significant lowering of (p < 0.05) of serum LDL from 28.53±12.2 mg/dl to 9.70 ± 5.77 mg/dL; the serum Cholesterol level from 92.00± 13.0 mg/dl to 60.33± 8.60 mg/dl; and the serum triglyceride leve1from 71.83 ± 13.0 mg/dl to 84.73±19.4 mg/dl and on the other hand for the same dose it had significant elevated serum HDL levels from 11.66 ±1.23 mg/dl to 29.66± 1.52 mg/dl. At the medium dose of 300mg /kg it was not effective as 400mg /kg and at the minimal dose of 200mg/kg brought numerical difference not statisticaly significant among the serum lipid profile. Conclusion: These observations suggest that HMECA has a dose dependent antihyperlipidemic effect against high fat diet induced hyperlipidemia. The molecular mechanism of antilipidemic activities of this drug need to be studied.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Calpurnia aurea, High fat diet, Hyperlipidemia, Lipid profile, Atorovastatin
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Africana
Depositing User: Emmanuel Ndorimana
Date Deposited: 31 Oct 2018 10:02
Last Modified: 31 Oct 2018 10:02
URI: http://thesisbank.jhia.ac.ke/id/eprint/7208

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