Amsalu, Meron (2016) Cross-Sectional Study on the Assessment of Dyslipidaemia Using Classical Lipid Profile and Apolipoprotein in Type 2 Diabetic Patients at the Diabetic Clinic of Tikur Anbessa Specialized Teaching Hospital. Masters thesis, Addis Ababa University.
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Abstract
Background: Type2 diabetes mellitus and its complication are becoming more prevalent in Ethiopia. It is estimated that 2-3 % of the population is living with diabetic. No Study is available in correlation of Apolipoprotein and lipid profile that is relevant in diagnosis and monitoring of diabetic dyslipidaemia in our local set up. Therefore the current study assessed the correlation of Apolipoprotein with lipid profile. Objective: Assessment of Dyslipidaemia using lipidprofile, lipid ratios and Apolipoprotein value in type 2 diabetic patients who are apparently healthy attending diabetic clinic of the Tikur Anbessa Specialized Teaching Hospital, Addis Ababa. Method: A Crossectional study was done during the study period from 15/10/2014 to 24/10/2016.Demographic variables were measured and Dyslipidaemia was assessed from overnight fasting serum sample by measuring Apolipoprotiens and lipid profile. Degree of association and/or correlation between Apolipoprotein and classical lipid profile was evaluated using Spearman, Pearson correlation, independent sample t test , Man Whitney test and Chi square appropriately. SPSS version 20 software was used and histogram, Box Plot and Scatter plot was used to display results. Result: A total of 70 type 2 Diabetic patients were participated in the study. Median age of the participants was 47(31-64). Dyslipidemia Observed in participants were high TC, low HDL, high LDL , high TG, low Apo A1, high Apo B100 ,high non HDL and high lipid ratios. Apo B 100 and Apo A1 are positively associated with LDL and HDL respectively. In additionlipid ratios had significant positive association with atherogenic lipid parameters and negative association with anti-atherogenic lipid parameters. Conclusion: Apolipoprotein A1 and B100 are associated with classical lipid profiles that help in diagnosis of dyslipidaemia in type 2 Diabetic patients
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 01 Nov 2018 09:01 |
| Last Modified: | 01 Nov 2018 09:01 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7242 |
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