Godefa, Yared (2014) The Role of Estrogen Receptors in Breast Cancer: A Review. Masters thesis, Addis Ababa University.
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Abstract
Estrogens play a significant role in regulating the growth and differentiation of normal, premalignant and malignant cell types, especially breast epithelial cells, through interaction with two nuclear estrogen receptors (ER alpha and ER beta). Estrogen receptor (ER) plays a central role in mediating the effects of endogenous hormones and endocrine therapy has been an integral treatment for patients with hormone-dependent breast cancers. ERis targeted either directly by selective estrogen receptor modulators and pure antagonists or indirectly by aromatase inhibitors that block estrogen production. A significant number of ER-positive patients, however, fail to respond to therapy or develop resistance over time.ER also serves as a prognostic marker for responsiveness to endocrine therapy. In this review, we present a brief overview of the role of ERs in breast carcinogenesis, including cancer progression to metastasis, and of their clinical importancein the prevention, treatment and prognosis of the disease.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 01 Nov 2018 08:56 |
| Last Modified: | 01 Nov 2018 08:56 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7246 |
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