Nigussie, Abebaw (2014) Serum Level of Β-Hcg in Normotensive and Pre-Eclamptic Pregnant Women Attending Antenatal Care at Tikur Anbessa Specialized Hospital: A Case-Control Study. Masters thesis, Addis Ababa University.
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Abstract
Background: Pre-eclampsia remains a major cause of prenatal morbidity and mortality worldwide. WHO estimated the incidence to be seven times higher in developing countries (2.8% of live births) than in developed countries (0.4%). Overall, pre-eclampsia and eclampsia accounts for 10%–15% of maternal deaths. Early identification of pregnant women at risk for pre-eclampsia is a priority to implement preventive measures. So far delivery is the only curative treatment. It is postulated that pre-eclampsia is likely to be a trophoblastic disorder. Since β-hCG is secreted by trophoblastic cells its serum level may be essential in diagnosing the disease. Objective: To assess the association between maternal serum level of β-hCG and pre-eclampsia Methods: A case control study was conducted on a total of 76 pregnant women with singleton pregnancies attending antenatal clinic during the period from June, 2013 to March, 2014 at Tikur Anbessa Specialized Hospital. Thirty eight normotensive pregnant women were grouped in controls and thirty eight pregnant women with pre-eclampsia were grouped in the cases. Serum level of β-hCG was determined by the electrochemiluminescence immunoassay (ECLIA) using cobas e 411 immunoassay analyzer. T-test, nonparametric tests and regression analysis were used for statistical analysis. A level of P< 0.05 was considered statistically significant. Result: The mean level of maternal serum β-hCG in the pre-eclamptic group was significantly higher than in the normotensive group (34439.18 ± 28223.67 Vs. 20582.00 ± 17588.31, p=0.012). However, significant difference was found only in multigravida women. Early onset pre-eclamptic group had higher mean level of β-hCG than late onset group but this was not statistically significant (p=0.539). Unlike the pre-eclamptic group, primigravida normotensive group had significantly higher serum β-hCG concentration than multigravida ones (p=0.026). Concentration of β-hCG was positively correlated with diastolic, systolic and mean arterial blood pressure (r= 0.23, 0.05, 0.15 and p= 0.17, 0.79 and 0.36 respectively) and negatively correlated with maternal age, gestational age and parity (r= -0.15, -0.21, -0.06 and p= 0.36, 0.20 and 0.71 respectively). Conclusion: The study found out a significantly higher serum level of β-hCG in multigravida pre-eclamptic women than in normotensive ones. It also found out a significantly higher level of β-hCG in primigravida than in multigravida normotensive women. Early onset pre-eclamptic group had higher level of β-hCG than late onset pre-eclamptic group.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Pre-eclampsia, human chorionic gonadotropin |
| Subjects: | Q Science > Q Science (General) Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 11 Jul 2018 12:06 |
| Last Modified: | 11 Jul 2018 12:06 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7271 |
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