Mengistu, Assegid Tassew (2007) Assessment of the Prevalence of Adverse Drug Reaction among HIV-Infected Adults on Anti Retroviral Therapy and Factors Associated With it at Zewditu Memorial Hospital. Masters thesis, Addis Ababa University.
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Abstract
Background: The success of Anti Retroviral Treatment (ART) is highly dependent on adherence to complex ARV regimens. Unfortunately, up to 25% of patients discontinue their initial HAART regimen mainly because of toxic effects. Objectives: To assess the magnitude of adverse drug reactions (ADRs) and associated factors among patients on Anti Retroviral Treatment Methods: Out of the source population that consisted of 3240 adult AIDS patients started on ART at Zewditu Memorial Hospital from January 2004 to December 2005, 554 study subjects’ clinical records were selected using systematic random sampling technique. The study was an institution based cross sectional study conducted using review of clinical records of adult patients on ART to examine the status of ADRs and factors associated with it among patients on ART. Independent predictors of the development of ADRs, types and severity were assessed with binary logistic regression. Results: Out of the total of 554 clinical records, 526 (94.9%) were reviewed. At least one of the drugs was changed in 120(22.8%) of the patients. There were 73 (13.7%) lost for follow up. The main reasons for changing ARV drugs were toxicity/side effects 97(81%) followed by illness in 14(12 %), and pregnancy in 4(3%). The frequency of ADRs was 124(24%). The most frequently diagnosed ADRs were Anemia 42(33.9%) followed by Peripheral Neuropathy 35 (28.2%) and Elevated ALT 31(25%). Majority 94(75.8%) of the ADRs were classified as grade III. Variables associated with ADRs were regimen containing NEV (OR=1.60; CI=1.04-2.47), treatment durations 6-10, 11-15 and >15 months OR 3.50 (1.47, 8.33), 3.36 (1.34, 8.40) and 5.08 (2.20, 11.75) respectively and taking other drugs (OR=1.80; CI=1.06- 3.03). Conclusions: Relatively very high rate of changing of drugs was noted with in first line regimen drugs, with high lost to follow up rate which may shorten the durability of the first line regimen. The most frequent ADR was anemia followed by Peripheral Neuropathy and Elevated ALT. The type of ADRs that the patient developed was very much associated with the duration of treatment and the regimen. Therefore, early diagnosis and appropriate management of ADRs is reckoned to decrease the rate of changing first line drugs which eventually maintain their efficacy and durability.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine |
| Divisions: | Africana |
| Depositing User: | Vincent Mpoza |
| Date Deposited: | 01 Nov 2018 09:36 |
| Last Modified: | 01 Nov 2018 09:36 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7298 |
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