A Research Paper to be Submitted to Department of Anesthesia College of Health Sciences, Addis Ababa University in Partial Fulfillment for the Requirement of the Master Degree in Anesthesia

Gashaw, Abebe (2017) A Research Paper to be Submitted to Department of Anesthesia College of Health Sciences, Addis Ababa University in Partial Fulfillment for the Requirement of the Master Degree in Anesthesia. Masters thesis, Addis Ababa University.

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Abstract

Background: - Suxamethoneum is a depolarizing muscle relaxant first introduce into clinical practice in 1951, it remains the drug of choice in clinical situations in which rapid paralysis and air way control are priorities. The administrations of succinylcholine may produce post-operative myalgia. Post-operative myalgia is thought to be caused by motor units firing at physiological higher rate following Suxamethoneum administration, leading to unsynchronized muscle contractions causing shearing forces of skeletal muscle fibers. The postoperative myalgia is generalized aches and pains that commonly occur 24 to 48 hours after Suxamethoneum Objectives: - To assess the magnitude and associated factors of Suxamethoneum induced post-operative myalgia in adult elective surgical procedures that were under gone from January 1, 2017 to March 1, 2017 in Zewuditu memorial hospital, Addis Ababa, Ethiopia. Method:-On 283 eligible patients Hospital based cross sectional study was conducted from January 1, 2017 to March 1, 2017 G.C at Zewuditu Memorial Hospital, using structured questionnaires and checklists and data were collected from all elective surgical patients who fulfill the inclusion criteria during study period and the magnitude of post-operative myalgia was calculated (%), associated factors with myalgia was investigated. Multivariate logistic regression analysis was conducted to identify significant predictors based on p-value less than 0.05 with 95% confidence level. Results:-Among 160 elective surgical patient the magnitude of Suxamethoneum induced post operative myalgia in the first 24 to 48hours were in 92(57.5%) and in which at 24hour the magnitude were about 84(52.5%) where as at 48 hour 74(46.2). The independent predictors of Suxamethoneum induced post operative myalgia in this study are being female, incidence fasciculation during induction and analgesia preoperatively. Conclusion and recommendation:-The magnitude of Suxamethoneum induced post operative myalgia in the first 24-48hrs was higher. To minimize the magnitude of Suxamethoneum induced post operative myalgia and post operative patient discomfort different prevention techniques should be applied. If possible it better to avoid the use of Suxamethoneum regularly for elective surgical patients. It is also recommended that premedication of patients with analgesic agent before induction anesthesia and defaciculat with NDNMBA.

Item Type:	Thesis (Masters)
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions:	Africana
Depositing User:	Vincent Mpoza
Date Deposited:	12 Jul 2018 10:32
Last Modified:	12 Jul 2018 10:32
URI:	http://thesisbank.jhia.ac.ke/id/eprint/7351

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