Studies on First Rowtransition Metal Complexes Derived from Ninhydrin and Amino Acids Having Polar (Threonine) and Nonpolar (Leucine) Side Chains

Getachew, Negash (2003) Studies on First Rowtransition Metal Complexes Derived from Ninhydrin and Amino Acids Having Polar (Threonine) and Nonpolar (Leucine) Side Chains. Masters thesis, Addis Ababa University.

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Abstract

Complexes of Co(II), Ni(II), and Zn(II) with Ruhmann’s purple, those of Fe(III) and Mn(II) with an intermediate Schiff base ( ketimine and / or aldimine) and Cu(II) with ninhydrin were successfully synthesized. All complexes were distinctly colored and stable to atmospheric conditions. The complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility, infrared and electronic spectral studies. The ligands were shown to behave as a monobasic tridentate ONO, bidentate ON or OO donor. The complexes of Zn(II), Co(II) and Ni(II) are purely Ruhmann’s purple, those of Mn(II) and Fe(III) are Schiff base (ketimine), Schiff base and ninhydrin or Schiff base and Ruhmann’s purple complexes. An octahedral geometry is proposed for all of the metal complexes, except Mn(II). A comparative anti- microbial study of the complexes was undertaken against two gram - negative bacteria, Escherichia coli and one gram - positive bacterium Staphylococcus aureus. It was revealed that except Cu(II) and to some extent Zn(II) complexes most of the complexes exhibit a reduced activity against both bacterium.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	metal complexes, Schiff base, ninhydrin, Ruhmann’s purple, α – Leucine, α–L–Threonine and antimicrobial activity
Subjects:	Q Science > QD Chemistry
Divisions:	Africana
Depositing User:	Emmanuel Ndorimana
Date Deposited:	19 Nov 2018 08:58
Last Modified:	19 Nov 2018 08:58
URI:	http://thesisbank.jhia.ac.ke/id/eprint/7511

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