Taye, Mignot (2016) Prevalence of Autoimmune Hemolytic Anemia in HIV Infected Anemic Adults, a Cross Sectional Study at Tikur Anbessa Specialized Teaching Hospital from June 5, 2015 to September 10, 2015, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background:- Hematologic manifestations in HIV/AIDS positive patients are many. A high prevalence of anemia and significantly reduced white blood cell and neutrophil counts were observed in HIV-infected individuals. Presence of auto antibody also contributes for the development of anemia in HIV positive individuals. Few studies are conducted to show the prevalence of anemia in HIV positive individuals, but there is no documented data that rule out the prevalence of AIHA in HIV positive individuals in Ethiopia. Objective:- To determine the prevalence of autoimmune haemolytic anemia in HIV-infected adult patients at Tikur Anbessa Specialized teaching Hospital, Addis Ababa, Ethiopia. Methods:- Hospital based cross sectional study was conducted on 384 HIV positive individuals using convenient sampling method at Tikur Anbessa Hospital from June 5, 2015 to September 10, 2015. Participants’ soco-demographic data, CD4 result and some important information was extracted from participants’ records; from patient card and request paper using Microsoft excel. And 5 ml of venous blood was collected for determination of HGB, RBC count, RBC indices, reticulocyte count and other CBC results. After all, DAT was performed and blood film examination was done to confirm hemolysis. Finally data was imported and analyzed using SPSS version 16 statistical soft ware package, and Descriptive statistic and Chi-square tests were used. Result:- Of 384 study participants, 9 (2.34 %) patients are found to be AIHA positive. Of these, 6 (66.7 %) were females and 3 (33.3 %) were males. Nineteen patients had positive DAT result; 10 (52.6 %) had mild anemia, 4 (21 %) moderate and 5 (26.3 %) severe anemia respectively. 37 (9.6 %) patients showed reticulocytopinea, while 31(8.1 %) patients had shown reticulocytosis. From 26 patients who showed evidence for the presence of hemolysis in their blood film, two individuals showed +2 graded hemolysis whereas 24 patients showed +1 graded hemolysis. Conclusion:- Prevalence of AIHA in HIV patients is not common. AIHA can be an etiological cause of anemia most of the time in patients with severe-moderate ranged anemia and in patients with low CD4 count.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Autoimmune haemolytic anemia, direct anti-globulin test, hemoglobin, reticulocytosis |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 19 Nov 2018 08:49 |
| Last Modified: | 19 Nov 2018 08:49 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7518 |
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