Lorato, Million Loha (2016) Evaluation of Acute and Subacute Toxicity of Methanol Extract of Syzygium Guineense Leaves on the Histology of the Liver and Kidney and Biochemical Compositions of Blood in Rats. Masters thesis, Addis Ababa University.
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Abstract
Plant medicine, is the oldest form of health care known to mankind. Syzygium guineense is one of the many species of Ethiopian medicinal plants which have a long history of use as remedies for various ailments such as dysentery, diarrhea and hypertension. In most countries, herbal medicines and related products are introduced into the market without any mandatory safety or toxicological evaluation. Therefore this study was conducted to investigate the histopathological effect of hydromethanol extract of S. guineense on liver and kidney; and blood parameters of rats. For acute toxicity study the rats were randomly divided into three groups (n=4). The control group received distilled water, while the experimental groups, received 2000 mg/kg and 5000 mg/kg 80% methanol extract of S.guineense leaves orally. For subacute toxicity study the rats were randomly divided into three groups (n=6). The control group received distilled water, while the experimental groups, received 500 and 1500mg/kg 80% methanol extract of S.guineense leaves orally for 28 days. At the end of the experiment, blood samples and liver and kidneys were collected for gross pathology, hematology, clinical chemistry and histopathology evaluation. In the acute toxicity study rats treated with 2000 and 5000mg/kg showed no toxicological signs observed on behavior, gross pathology, and body weight of rats. In the subacute toxicity study rats have showed no significant changes on behavior, gross pathology, body weight, hematological and biochemical parameters except glucose (p ˂ 0.05) as compared with the control group. There were no significant differences in the gross and histopathology of the liver and kidneys of experimental animals in extract exposed groups and their counterpart control. These results show that hydromethanol extract of S. guineense did not produce adverse effects in treated rats after acute and subacute treatment. Reduction in serum blood glucose level may indicate its therapeutic values, but further detailed studies should be carried out to recommend its therapeutic use.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Syzygium guineense, medicinal plant, toxicological evaluation |
| Subjects: | Q Science > QM Human anatomy R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 01 Nov 2018 11:13 |
| Last Modified: | 01 Nov 2018 11:13 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7526 |
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