Jemal, Mohabaw (2017) Bacterial Bloodstream Infections and Their Antimicrobial Susceptiblity Pattern among HIV/AIDS Patients at Felege Hiwot Referral Hospital, Bahir Dar, Amahara Regional State, North West Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Bacterial bloodstream infections are important opportunistic infections which cause high morbidity and mortality among HIV infected individuals. Bacterial bloodstream infections among HIV/AIDS Patients in Ethiopia is poorly known. Therefore, determining the etiological agents of bacterial bloodstream infections and their in vitro antimicrobial susceptibility pattern among HIV infected patients in Ethiopia is one of the highest priorities. Objective: The aimed of this study was to determine the extent of bacterial bloodstream infections and their in vitro antimicrobial susceptibility pattern among HIV/AIDS patients attending ARTclinic from July 15, 2016 to December 15, 2016 G.C at Felege Hiwot Referral Hospital, Bahir Dar, Amhara National Regional State North West Ethiopia. Methods and Materials: A hospital based cross sectional study was conduct among 384 HIV/AIDS patients attending ART- clinic at Felege Hiwot Referral Hospital during the study period. Venous blood samples were collected under strict aseptic condition. Collected blood samples were inoculated on blood culture bottles and incubated aerobically at 37o c for seven days for the presence of visible sign of microbial growth. Sub cultures were done on the BAP, CAP and MAC (Oxoid). Microorganisms were isolated and identified using standard biochemical techniques. Antimicrobial susceptibility tests for each isolated bacteria were determined by disc diffusion method. Quality of the data was assured through standard operational procedures (SOPs). Data was entered, checked for completeness and analyzed using SPSS version 20. Result: This study confirmed that among HIV/AIDS patients, 123 (32%) were infected with bacteremia. Prevalence of blood stream infection was higher in 1-14 years of age group (53.8%) than other age group. Higher percentage of positive blood culture isolates among HIV/AIDS patients having CD4 count of <200 cells/�L (76.5%) and used of intravenous catheter (68.6%).The major isolates were Staphylococcus aureus 49.3% (38/77), Coagulase Negative Staphylococcus 35% (n=27/77) and Klebsiella pneumoniae 41.3% (19/46). Majority of isolates 50(40.7%) were resistant to five and above antimicrobial agents.Conclusion: Prevalence of bacterial blood stream infections (32%) among HIV/AIDS patients was higher in this study. Positive blood culture isolates was higher among hospitalized HIV/AIDS patients with intravenous catheter and low CD4+ lymphocyte count. The most leading pathogens were S. aureus, CONS and K. pneumonia and majority of isolates were multidrug resistant bacteria.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Bacteremia, HIV, Antimicrobial Susceptibility patter |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 21 Nov 2018 08:26 |
| Last Modified: | 21 Nov 2018 08:26 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7552 |
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