Hassen, Mohammed Suaudi (2016) Pulmonary Tuberculosis and Hematological Profiles among Tuberculosis Suspected Patients in Selected Hospitals of Oromia Regional State, Ethiopia. Masters thesis, Addis Ababa University.
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PDF (Pulmonary Tuberculosis and Hematological Profiles among Tuberculosis Suspected Patients in Selected Hospitals of Oromia Regional State, Ethiopia)
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Abstract
Background: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is considered as an old enemy that exist for the last 70,000 years. Hematological abnormality is among the secondary complications in TB patients, which is less addressed in Ethiopia and in Oromia regions in particular. Objective: To determine the burden of pulmonary tuberculosis and selected hematological abnormalities among tuberculosis suspected cases in selected Oromia hospitals. Methodology: A cross-sectional study was conducted from December 2015 to May 2016 in Oromia regional states selected hospitals. A total of 188 sputum samples were collected and processed for the presence of pulmonary TB using ZN, FM and Xpert MTB/ RIF assay at Oromia public health research capacity building and quality assurance laboratory. Hematological parameters were determined using Cell-Dyn 1800 hematology analyzer. Socio-demographic data were collected using data collection format. Provider initiated HIV counseling and testing (PICT) was carried out as part of the standard care following the national algorithm. Data were entered, and analyzed using SPSS version 20. Descriptive statistics were applied to determine proportion and Chi2 test to see an association between PTB and the various hematological and socio-demographic variables. P value < 0.05 was taken as statistically significant. Results: Of the total 188 pulmonary TB presumptive patients, 116 (61.7%) were females and the mean SD age of participants was 31.3 ± 15.6 years. A total of 78 (41.5 %) participants were positive for MTB, of which 2/78 (2.6 %) were MDR cases. About 46 % of the study participants were HIV positive with a higher magnitude of 56.4% being recorded among PTB positives. Thrombocytopenia was noted in 86 (45.7 %) and anemia in 77 (41%) of all the suspects. Anemia was frequently encountered in patients with PTB (57.7 %). Among the anemic, majority were PTB positive females (53, 2%), followed by PTB negative females (24.7%), PTB positive males (15.6%), and least affected were PTB negative males (6.5%) Majority of the patients (57/78, 73.1%) had lower MCV and MCH values in presumptive TB cases. Though total leucocyte count did not differ, PTB patients were more neutropenic than PTB negatives. Conclusion: More than 70 % PTB patients had hematological abnormalities. Monitoring hematological parameters of TB patients has to be strengthened to benefit patients from TB treatment.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | GeneXpert MTB/RIF, LED FM, Zeihl Nelsen, TB/HIV, Hematological parameters |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 20 Nov 2018 09:32 |
| Last Modified: | 20 Nov 2018 09:32 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7574 |
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