Nurahmed, Negash (2017) Bacterial Profile and Antimicrobial Susceptibility Patterns of Lower Respiratory Tract Infection among Patients Attending Selected Health Centers’ of Kolfe Keraniyo Sub City, Addis Ababa, Ethiopia, 2016. Masters thesis, Addis Ababa University.
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Abstract
Background: Lower respiratory tract infections are the commonest health problem demanding frequent consultation and hospitalization. Moreover, in recent years, there has been dramatic rise in antibiotic resistance among respiratory pathogens. There are limited information concerning Lower respiratory tract infections burden and Antimicrobial resistance pattern in Ethiopia. Objective: To determine bacteriologically confirmed burden, profile and antibiotic susceptibility pattern of bacteria causing lower respiratory tract infections. Methodology: Using a cross-sectional study design a total of 240 samples were recruited from selected health centers’ of Kolfe Keraniyo sub city ,Addis Ababa, Ethiopia from May - July, 2016. Sputum samples were collected by using convenient sampling technique and inoculated on to MacConkey agar, Chocolate agar and blood agar and then incubated for 24 hrs at 37oc. Biochemical tests were performed and antimicrobial susceptibility testing was done using disk diffusion method. Data were entered and analyzed using Stastical Package for Social Sciences version 20. P values <0.05 was considered statistically significant. Results: From a total of 240 samples processed 77 (32.1%) showed growth of various species of bacteria. Among the isolates, K. pneumoniae 28 (36.4%) was the most isolated organism, S. pneumoniae 15 (19.5%) was next, followed by E. coli 10 (12.9 %).Gram-negative bacilli were highly sensitive to Meropenem (98%), Tobramycin (93 %), Amikacin (90%), ceftazidime (90%) and Ceforoxime (90%) while highly resistance to Ampicilin (83%), Tetracyclin (53%), Ciprofloxacilin (34%) and Trimethoprim-sulfamethoxazole (31%). Conclusion: Even though, the results obtained in this study indicated that some of the antibiotics used to treat respiratory tract infections in this community are effective, but still there is danger of drug resistance which need to be tackled. Hence regular monitoring of LRTI etiologies and antimicrobial drug resistance testing is essential to maximize the shelf life of effective drugs.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Lower Respiratory Tract Infection, Bacterial Agents, Antimicrobial susceptibility patterns |
| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 27 Nov 2018 10:30 |
| Last Modified: | 27 Nov 2018 10:30 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7729 |
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