Debero, Nigussie (2013) Impact of First Generation Antipsychotics in the Long Term Outcome of Bipolar I Disorder, a Community-Based Naturalistic Follow-Up Study, Butajira, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Bipolar disorder is one of the most severe forms of mental disorders, and is clinically characterized by profound mood swings. Bipolar disorder is an episodic condition requiring long-term, often life-long, treatment to control acute symptoms and stabilize mood. Despite recommendations by some treatment guidelines to avoid use of first generation antipsychotics(FGAs) in maintenance treatment of bipolar disorder, their use is highly prevalent especially in resource limited countries like Ethiopia. Objective: To assess the impact of the long term use of FGAs in the course and outcome of bipolar I disorder. Methods: The Longitudinal Interval Follow-up Evaluation(LIFE) chart was used to collect detailed psychosocial, psychopathologic and treatment outcome information. Results: Among the study participants who were at risk for relapse, 86.5% had experienced relapse during their follow-up. Duration on daily FGAs dose ≥ 300mg Chlorpromazine(CPZ) equivalents was significantly associated with relapse rate in bipolar I disorder. While FGAs use did not predict remission and overall functioning improvement, remission was negatively associated with duration of treatment on daily FGAs dose ≥ 300mg CPZ equivalents. Furthermore, duration on FGAs significantly increased the risk for EPS. On the other hand, FGAs use did not predict suicidality in bipolar I patients.Conclusion: Findings from the current study suggest that benefits of the long term use of FGAs in bipolar disorder are doubtful. Therefore, providing access to effective medications such as mood stabilizers may be relevant next steps to optimize the outcome of bipolar disorder in settings where FGAs are widely used.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | First generation antipsychotics, bipolar disorder, maintenance treatment, prophylaxis, outcome, Ethiopia |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 27 Nov 2018 12:11 |
| Last Modified: | 27 Nov 2018 12:11 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7777 |
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