Jibril, Oumer (2016) The Molecular Forms of Alzheimer Disease in Humans: A Review. Masters thesis, Addis Ababa University.
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Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized clinically by memory and cognitive dysfunction and also protein misfolding-based rapid cognitive impairment in the aging brain. It can inhibit the protein expression of specific genes by activating a sequence-specific RNA degradation process. This is a powerful tool with which to study gene function, investigate the mechanism of the disease, and validate drug targets. In this review, we summarize the systems biology data on AD and pay particular attention to the proteomic changes in AD. Applying a systems biology model of the synapse, we attempt to integrate protein changes and provide an explanation of why seemingly diverse molecular changes result in memory impairment. Finally, we give a systems biology model of AD explaining how AD can develop in an individual manner in each particular subject but always results in a rapidly developing dementia and memory impairment. Unfortunately, there is no effective therapeutic method for AD treatment or ways to halt disease progression. Many mechanisms are involved in the disease, including genes mutation and protein dysfunction.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 27 Nov 2018 10:46 |
| Last Modified: | 27 Nov 2018 10:46 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7802 |
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