Alemu, Rahel (2016) Comparative Cross-sectional Study on Prevalence and Associated Factors of Anemia in HAART Naïve and HAART Experienced Adult HIV Patients at Zewditu Memorial Hospital, Addis Ababa, Ethiopia. Masters thesis, Addis Ababa University.
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Abstract
Background: Hematological abnormalities are manifested in human immunodefieicincy virus patients as a result of progressive damage to the body’s immune system. They are documented to be the second most common causes and strong independent predictor of mortality and morbidity in people living with HIV/AIDS. Objective: To determine prevalence and associated factors of anemia in highly active antiretroviral therapy (HAART) naïve and HAART experienced adult HIV positive individuals. Methodology: A hospital based comparative cross sectional study was conducted from April to November, 2015 at Zewditu Memorial Hospital, Addis Ababa, Ethiopia. A total of 340 HIV infected adult individuals, 170 HAART naïve and 170 HAART experienced, were enrolled in the study. Participant’s socio-demographic and clinical information were collected using pre-tested structured questionnaire. Blood and stool specimen were collected from each participant. Blood was examined for full blood count, CD4 and hemoparasite. Stool samples were screened to detect intestinal parasites. Descriptive statistics were used to express the socio-demographic characteristics of the participants. Binary and multiple logistic regressions were computed to assess association between variables using SPSS version 20. P value less than 0.05 was taken as statistically significant. Result: - The overall all prevalence of anemia was 15.44%. The prevalence of anemia in HAART Naïve and HAART experienced patients was 24.71% and 7.1% respectively. Advanced WHO clinical stage (AOR= 9.63, 95% CI= 1.07-86.95), low CD4+ T cells count (<200) (AOR= 7.57; 95% CI= 2.17- 27.01), and body mass index <18.5 (AOR= 7.56; 95% CI= 2.12-27.01) were found to be predictors of anemia in HAART naïve patients. On the other hand, none of the variables was found to be independently associated with anemia in HAART Experienced patients. Conclusion: -Anemia is the common manifestation both in HAART naïve and HAART experienced patients. However, Prevalence of anemia is higher in HAART naïve HIV individuals than those on HAART. Therefore; further longitudinal study should be conducted to map every possible correlates of anemia and compare its burden in HAART Naïve and HAART experienced adult HIV patients.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Anemia, HAART-naïve, HAART- experienced, Risk Factors |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 29 Nov 2018 09:44 |
| Last Modified: | 29 Nov 2018 09:44 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7821 |
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