Kiflu, Rigbe (2016) The Effect of Chronic Caffeine Intake on the Cardiovascular System: A Review. Masters thesis, Addis Ababa University.
![[img]](http://thesisbank.jhia.ac.ke/style/images/fileicons/application_pdf.png) |
PDF (The Effect of Chronic Caffeine Intake on the Cardiovascular System: A Review)
RIGBE KIFLU.pdf - Accepted Version Restricted to Repository staff only Download (1MB) | Request a copy |
Abstract
Caffeine is one of the main active ingredients found in a stimulant drinks probably the most frequently ingested in the world. It is one of a group of plant alkaloids which occurs naturally in the leaves, seeds and fruit of more than sixty plant species of which coffee, cocoa beans, tea, mate leaves and guarana berries are the most well known. Caffeine constitutes one to two percent of roasted coffee beans, 3.5 percent of fresh tea leaves, approximately two percent of mate leaves and guarana, a plant containing caffeine which is used in preparation of soft drinks (energy drinks) contains two times of coffee beans. Cytochrome P450 1A2 (CYP1A2) is the main responsible enzyme for the metabolism of caffeine in to its three metabolites including parathanthine, theophylline and theobromine. Unlike many other psychoactive substances it is legal and unregulated in nearly all parts of the world because of its wide consumption at different levels by most segments of the population. Coffee is commonly consumed among all peoples of groups of irrespective of age, race, sex, culture in Ethiopia. However, consumers are rarely aware of adverse effects as a result of excessive consumption of caffeine. The risks of suffering from any of the harmful effects of caffeine on CVD are diminished by being aware of how much is personally being consumed daily. However findings have been contradictory as results are similarly conflicting and generalizations are complicated by differences in age, gender, health status and serving size. The main objective of this review was to address the specific effects of chronic caffeine intake on the cardiovascular system of which caffeine’s mechanisms of action (focusing on the role of caffeine on the blockade of cardiac adenosine receptors which leads to tachycardia and arrhythmias, by upregulation of circulating catecholamine which increases chronotropy and dromotropy with an increased heart rate and conductivity). Moreover, this review tried to compare the effect of acute, moderate and chronic caffeine consumption in which peoples that are habitual, nonhabitual and chronic consumers, including individuals susceptible to cardiac case are prone for the adverse effect of caffeine. High usual caffeine intake greater than 400 mg is believed to moderately account for an elevated risk of blood pressure, arrhythmias, arterial stiffness and also may aggravate heart attack. Moreover,coffee caffeine consumption more than 10 cups per day is an independent risk indicator for sudden cardiac arrest due to sustained ventricular tachycardia or ventricular fibrillation.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Caffeine; Coffee; Cardiovascular diseases; chronic consumption |
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 28 Nov 2018 10:59 |
| Last Modified: | 28 Nov 2018 10:59 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7882 |
Actions (login required)
 |
View Item |