Debebe, Selamawit (2005) Asymptomatic Bacteriuria in Pregnant Women in Harar, South Eastern Ethiopia. Masters thesis, Addis Ababa University.
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PDF (Asymptomatic Bacteriuria in Pregnant Women in Harar, South Eastern Ethiopia)
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Abstract
Asymptomatic bacteriuria (ASB) is a common problem in pregnant women, which usually results in maternal and fetal complications. The objective of this study was to assess the prevalence of ASB in pregnant women in Harar Town, Southeastern Ethiopia, to identify the significant pathogens, and analyze their susceptibility pattern to selected antimicrobial agents. A cross sectional study was conducted on a clean–catch mid stream morning urine collected from 278 asymptomatic pregnant women attending antenatal clinic, in Misrak Arbegnoch hospital and family guidance association clinic Harar town from Feb–Apr2005. The age range of the study subject was from 15-40 years. The majority was in the second trimester 129 (46%). Out of 278 morning clean catch mid stream urine processed, 24 specimens were found to have significant bacteriuria with a prevalence rate of 8.6%. E. coli (50%) was found to be the predominant infecting organisms followed by K. pneumoniae (16.6%). Past history of urinary tract infection was found to have a significant association with asymptomatic bacteriuria (OR= 4.593; P=0.001). Majority of the isolates showed resistance to ampicillin, amoxicillin, and cephalotin. Almost all of the Gram positive and Gram-negative organisms were sensitive for ciprofloxacin. The sensitivity, specificity, positive predictive value and negative predictive value of leukocyte esterase were 67%, 90%, 38%, and 96% respectively. Similarly, nitrite had a sensitivity of 50%, specificity of 93%, positive predictive value of 41%, and negative predictive value of 95%. In conclusion, all pregnant women should be screened and treated for bacteriuria in their antenatal follow up, Reagent strip test and microscopy alone can not be used for screening of pregnant women as a result where culture facilities are not available, a combination of rapid tests is recommended. Ciprofloxacin and nitrofurantoin are good alternatives for treatment of asymptomatic bacteriuria in pregnant women. The investigation of risk factors associated with asymptomatic bacteriuria in a larger study population, and continuous monitoring of the drug susceptibility of uropathogens are recommended.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Asymptomatic bacteriuria, pregnancy, urinary tract pathogens, antimicrobial susceptibility testing |
| Subjects: | Q Science > QR Microbiology Q Science > QR Microbiology > QR180 Immunology |
| Divisions: | Africana |
| Depositing User: | Emmanuel Ndorimana |
| Date Deposited: | 20 Jul 2018 13:01 |
| Last Modified: | 20 Jul 2018 13:01 |
| URI: | http://thesisbank.jhia.ac.ke/id/eprint/7955 |
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